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Relationships between G-protein-coupled receptor families




Three different families of G-protein coupled receptors have been characterized; the largest is the rhodopsin family, which includes cationic amine receptors (dopamine, acetylcholine, etc), prostanoids, odorants, and many other hormones. A schematic evolutionary tree for the family is shown above. In addition to the rhodopsin family, two other families of G-protein-coupled receptors are known - the secretin/calcitonin family and the glutamate receptor family.


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