Exploring Distant Protein Sequence Relationships

Introduction - Homology and Sequence Similarity

The tree of life - how far back can we see?

Homology and similarity - the globin family

Similarity scores and sequence length

Accurate statistics with Smith-Waterman

Accurate statistics with FASTA

Accurate statistics for DNA

Protein vs DNA sequence comparison

Examining marginal sequence relationships

G-protein coupled receptors

Relationships between G-protein coupled receptors

Linking rhodopsin and secretin/calcitonin families

Beter statistics with higher gap penalties

Relationships between calcium binding proteins

Searching with a short domain

Improvements to FASTA

Summary

Suggested reading