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Books
- Friesen WO, Friesen, JA (2010) NeuroDynamix II. Concepts of Neurophysiology Illustrated by Computer Simulations.
New York: Oxford University press, 228 pp
- Friesen
WO, Friesen JA (1994) NeuroDynamix.
Computer Models for Neurophysiology. New York: Oxford University
press, 203 pp
Major
Computer Software
1.
Friesen
WO, Friesen, JA (2009) NeuroDynamix II. Neuronal
simulation models with preprogrammed lessons; available on-line without
charge at www.neurodynamix.net
2.
Hocker CG,
Friesen WO (1997) Rhythm Analysis
System (RAS). Software for analyzing rhythmic
neurophysiological data (period, impulse frequencies, phase and statistics);
freely available by contacting wof@virginia.edu
3.
Friesen
WO, Friesen, JA (1994) NeuroDynamix. Neuronal
simulation models with preprogrammed lessons
Top of page | Books | Computer programs | Leech
neurobiology | Reviews | Modeling, comments,
and miscellany | Lobster
cardiac ganglion physiology| Cardiovascular
physiology | Technical
Leech Neurobiology Research
- Iwasaki T, Chen J,
Friesen WO (2014) Biological clockwork underlying adaptive rhythmic
movements. PNAS 111:978-983 (Full Text)
- Mullins OJ, Friesen WO (2012) The brain
matters: Effects of descending signals on motor control. J Neurophysiol. 107:2730-41 (Full Text)
- Chen J, Friesen WO, Iwasaki T (2012) Mechanisms
underlying rhythmic locomotion: interactions between activation, tension
and body curvature waves. J Exp Biol 215:211-219 (Full Text)
- Mullins OJ, Brodfuehrer
PD, Jusufović S, Hackett JT, Friesen WO
(2012) Specialized brain regions and sensory inputs that control
locomotion in leeches. J Comp Physiol A 198:
97-108 (Full Text)
- Friesen, WO,
Mullins OJ, Xiao, R, Hackett, JT (2011) Positive feedback loops sustain
repeating bursts in neuronal circuits. J Biol
Physics 37:317-334
(Full Text)
- Chen J, Tian J, Iwasaki T, Friesen WO (2011) Mechanisms
underlying rhythmic locomotion: dynamics of muscle activation. J Exp Biol 214:1955-1964 (Full Text)
- Chen J, Friesen
WO, Iwasaki T (2011) Mechanisms underlying rhythmic locomotion:
body-fluid interaction in undulatory swimming.
J Exp Biol
214:561-574 (Full Text)
- Mullins OJ,
Hackett, JT, Friesen, WO (2011) Local-distributed integration by a novel
neuron ensures rapid initiation of animal locomotion. J
Neurophysiol
105:130–144 (Full Text))
- Tian J, Iwasaki T, Friesen WO (2010) Analysis of
impulse adaptation in motoneurons. J Comp Physiol A 196:123-136 (Full Text)
- Tian J, Iwasaki T, Friesen WO. (2007) Muscle function in
animal movement: Passive mechanical properties of leech muscle. J Comp Physiol 193:1205-1219 (Full Text)
- Fan RJ, Friesen
WO (2006) Morphological and physiological characterization of stretch
receptors in leeches. J Comp Neurol
494:290-302 (Full Text)
- Fan RJ,
Marin-Burgin, A, French, KA, Friesen WO (2005) A dye mixture (Neurobiotin and
Alexa 488) reveals extensive dye-coupling among neurons in leeches; physiology
confirms the connections. J Comp Physiol
191:1157-1171(Full Text)
- Yu X, Friesen WO
(2004) Entrainment of leech swimming activity by the ventral stretch
receptor. J Comp Physiol A 190:939-949 (Full Text)
- Cang J, Friesen WO (2002) Model for intersegmental coordination of leech swimming:
Central and sensory mechanisms. J Neurophysiol
87:2760-2769 (Full Text)
- Cang J, Yu X,
Friesen WO (2001) Sensory Modification of Leech Swimming: Interactions
between Ventral Stretch Receptors and Swim-related Neurons. J Comp Physiol A 187: 569-579 (Full Text)
- Friesen WO, Hocker CG. (2001) Functional analyses of the leech
swim oscillator. J Neurophysiol 86:824-835 (Full Text)
- Hocker CG, Yu X,
Friesen WO (2000) Functionally heterogeneous
segmental oscillators generate swimming movements in the medicinal
leech. J Comp Physiol 186:871-883 (Full Text)
- Cang J, Friesen WO
(2000) Sensory modification of leech swimming: Rhythmic activity of
ventral stretch receptors can change intersegmental
phase relationships. J Neurosci 20:7822-7829 (Full Text)
- Yu X, Nguyen B,
Friesen WO (1999) Sensory Feedback Can Coordinate the Swimming Activity
of the Leech. J Neurosci 19:4634-4643 (Full Text)
- O'Gara BA,
Friesen WO (1995) Termination of leech swimming activity by a previously
identified swim trigger neuron. J Comp Physiol 177:627-636 (Full Text)
- Mangan PS, Cometa AK, Friesen WO (1994) Modulation of swimming
behavior in the medicinal leech. IV. Serotonin-induced alterations of
synaptic interactions between neurons of the swim circuit, J Comp Physiol 175:723-736 (Full Text)
- Mangan PS, Curran GA, Hurney CA, Friesen WO (1994) Modulation of swimming
behavior in the medicinal leech. III. Control of cellular properties in motor
neurons by serotonin, J Comp Physiol
175:709-722 (Abstract) (Full Text)
- Angstadt JD, Friesen WO
(1993) Modulation of swimming behavior in the medicinal leech. I.
Effects of serotonin on the electrical properties of swim-gating cell
204. J. Comp Physiol. A 59:223-234 (Abstract)
- Angstadt JD, Friesen WO
(1993) Modulation of swimming behavior in the medicinal leech. II. Ionic
conductances underlying serotonergic
modulation of swim-gating cell 204. J. Comp Physiol. A 59:235-248 (Abstract)
- Gray RA, Friesen
WO (1993) Identification of leech neurons using a resonance technique.
Proceedings of the Computation and Neural Systems Meeting, San Francisco
(Full Text)
- Brodfuehrer PD, Kogelnik AM, Friesen WO, Cohen AH (1993) Effect of
the tail ganglion on swimming activity in the leech. Behav
Neural Biol 59:162-166 (Abstract)
- O'Gara BA, Chae H, Latham LB, Friesen WO (1991) Modification of
leech behavior patterns by reserpine-induced amine depletion. J Neurosci 11:96-110 (Full Text)
- Angstadt JD, Friesen WO
(1991) Synchronized oscillatory activity in leech neurons induced by
calcium channel blockers. J Neurophysiol
66:1858-1873 (Full Text)
- Friesen WO
(1989) Neuronal control of leech swimming movements. I. Inhibitory
interactions between motor neurons. J Comp Physiol
A 166:195-203 (Abstract)
- Friesen WO
(1989) Neuronal control of leech swimming movements. II. Motor neuron
feedback to oscillator cells 115 and 28. J Comp Physiol
A 166:205-215 (Abstract)
- Hashemzadeh-Gargari H, Friesen WO
(1989) Modulation of swimming activity in the medicinal leech by
serotonin and octopamine. Comp Biochem Physiol
94C:295-302 (Abstract)
- Pearce RA,
Friesen WO (1988) A model for intersegmental coordination in the leech nerve cord.
Biol Cybernetics 58:301-311 (Full Text)
- Debski EA, Friesen WO
(1987) Intracellular stimulation of sensory cells elicits swimming
activity in the medical leech. J Comp Physiol
A 160:447-457 (Abstract)
- Nusbaum MP, Friesen WO,
Kristan WB Jr,
Pearce RA (1987) Neural mechanisms generating
the leech swimming rhythm: Swim-initiator neurons excite the network of
swim oscillator neurons. J Comp Physiol A
161:355-366 (Abstract)
- Brodfuehrer PD, Friesen WO
(1986) Control of leech swimming activity by cephalic ganglia. J Neurobiol 17:697-705 (Full Text)
- Brodfuehrer PD, Friesen WO (1986)
Initiation of swimming activity by trigger neurons in the leech
subesophageal ganglion. I. Output pathways of Tr1 and Tr2. J Comp Physiol 159:485-502 (Abstract)
- Brodfuehrer PD, Friesen WO
(1986) Initiation of swimming activity by trigger neurons in the leech
subesophageal ganglion. II. Role of segmental swim-initiating
interneurons. J Comp Physiol A 159:503-510 (Abstract)
- Brodfuehrer PD, Friesen WO
(1986) Initiation of swimming activity by trigger neurons in the leech
subesophageal ganglion. III. Sensory inputs to Tr1 and Tr2. J Comp Physiol A 159:511-519 (Abstract)
- Brodfuehrer PD, Friesen WO
(1986) From stimulation to undulation: An
identified pathway for the control of swimming activity in the leech.
Science 234:1002-1004 (Abstract)
- Debski EA, Friesen WO
(1986) The role of central interneurons in the
habituation of swimming activity in the medicinal leech. J Neurophysiol 55:977-994 (Full Text)
- Debski EA, Friesen WO
(1985) Habituation of swimming activity in the medicinal leech. J Exp Biol 116:169-188 (Abstract)
- Friesen W (1985)
Neuronal control of leech swimming movements: interactions between cell
60 and previously described oscillator neurons. J Comp Physiol A 156:231-242 (Abstract)
- Granzow BL, Friesen WO,
Kristan WB Jr (1985)
Physiological and morphological analysis of synaptic transmission
between leech motor neurons. J Neurosci
5:2035-2050 (Full Text)
- Pearce RA,
Friesen WO (1985) Intersegmental coordination
of the leech swimming rhythm. I. Intrinsic period gradient and coupling
strength. J Neurophysiol 54:1444-1459 (Full Text)
- Pearce RA,
Friesen WO (1985) Intersegmental coordination
of the leech swimming rhythm. II. Comparison of long and short chains of
ganglia. J Neurophysiol 54:1460-1472 (Full Text)
- Brodfuehrer PD, Friesen WO
(1984) A sensory system initiating swimming activity in the medical
leech. J Exp Biol
108:341-355 (Full Text)
- Pearce RA,
Friesen WO (1984) Intersegmental coordination
of leech swimming: comparison of in situ and isolated nerve cord
activity with body wall movement. Brain Res 299:363-366 (Full Text)
- Phillips CE,
Friesen, WO (1982) Ultrastructure of the water-movement-sensitive sensilla in the medicinal leech. J Neurobiol 13:473-486 (Full Text)
- DeRosa YS, Friesen WO
(1981) Morphology of leech sensilla: observations
with the scanning electron microscope. Biol
Bull 160:383-393 (Abstract) (Full Text)
- Young SR, Dedwylder RD II, Friesen WO (1981) Responses of the
medicinal leech to water waves. J Comp Physiol
144:111-116 (Abstract)
- Friesen WO
(1981) Physiology of water motion detection in the medicinal leech. J Exp Biol 92:255-275 (Full Text)
- Stent GS, Kristan WB Jr, Friesen WO,
Ort CA, Poon M, Calabrese RL (1978) Neuronal generation of the leech
swimming movement. Science 200:1348-1357 (Full Text)
- Poon M, Friesen
WO, Stent GS (1978) Neuronal control of swimming in the medicinal leech:
V. Connexions between oscillatory interneurons
and the motor neurones. J Exp
Biol 75:45-63 (Full Text)
- Friesen WO, Poon
ML, Stent GS (1978) Neuronal control of swimming in the medicinal leech:
IV. Identification of a network of oscillatory interneurones.
J Exp Biol 75:25-43 (Full Text)
- Friesen WO, Poon
ML, Stent GS (1976) An oscillatory neural
circuit generating a locomotory rhythm. Proc Nat Acad Sci 73:3734-3738 (Full Text)
- Friesen WO,
Stent GS (1977) Generation of a locomotory
rhythm by a neural network with recurrent cyclic inhibition. Biol Cybernetics 28:27-40 (Full Text)
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Leech neurobiology | Reviews | Modeling, comments,
and miscellany | Lobster
cardiac ganglion physiology| Cardiovascular
physiology | Technical
Reviews
- Mullins OJ, Hackett, JT,
Buchanan, JT and Friesen, WO (2011) Neuronal Control of Swimming
Undulations: Vertebrate versus Invertebrate. Prog
Neurobiol,
93:244–269 (Full
Text)
- Friesen WO (2010)
Neuronal circuits that generate swimming movements in leeches. In:
Shepherd G and Grillner S (eds.) Handbook of Brain Microcircuits.
New York: Oxford University Press, pp 462-469
- Friesen, WO (2010) Reciprocal Inhibition. In Encyclopedia
of Psychology and Behavioral Science, 4rd edition, Vol 4, (eds), New York:
Wiley & Sons
- Friesen,
WO (2009) Central pattern generators: Sensory feedback. In: Squire LR
(ed.) Encyclopedia of Neuroscience. Volume 2, pp. 701-709. Oxford:
Academic Press
- Friesen WO, Kristan WB (2007) Leech locomotion: swimming, crawling, and decisions,
Curr Opin Neurobiol 17:1–8 (Full
Text)
- Kristan WB, Calabrese R, Friesen WO (2005) Neuronal control of leech
behavior. Prog in Neurobiol
76:279-327 (Full
Text)
- Friesen WO, Cang J (2001) Sensory and central mechanisms control
of intersegmental coordination. Cur Opin in Neurobiol
11:678-683.(Full
Text)
- Friesen, WO (2000) Reciprocal Inhibition. In The
Corsini Encyclopedia of Psychology and
Behavioral Science, 3rd edition, Vol 4,
Craighead WE & Nemeroff CB (eds), New York: Wiley & Sons, 1375-1377
- Brodfuehrer PD, Debski EA,
O'Gara BA, Friesen WO (1995) Neuronal control of swimming. J Neurobiol 27:403-418 (Full
Text)
- Friesen WO (1994) Reciprocal Inhibition: A
Mechanism Underlying Oscillatory Animal Movements. Neurosci
and Biobehav Rev 18:547-553 (Full
Text)
- Friesen WO, Pearce RA (1993) Mechanisms of intersegmental coordination in leech locomotion. Sem Neurosci 5:41-47 (Full
Text)
- Friesen WO (1989) Hierarchical organization of
neuronal circuits that control animal locomotion. In: Erber J, Menzel R, Pflüger H-J, Todt D (eds) Neural Mechanisms of Behavior. Georg Thieme Verlag, New York
pp, 105-110
- Friesen WO (1989) Neuronal control of leech
swimming movements. In: Jacklet JW (ed) Cellular and Neuronal
Oscillators. Marcel Dekker, New York pp, 269-316 (Abstract)
- Friesen WO, Stent GS (1978) Neural circuits for
generating rhythmic movements. Ann Rev Biophys
and Bioeng 7:37-61 (Abstract) (Full
Text)
Top of page | Books
| Computer programs
| Leech neurobiology
| Reviews | Modeling, comments, and
miscellany | Lobster cardiac ganglion physiology| Cardiovascular physiology | Technical
Modeling, comments, and miscellany
1. Casiraghi LP, Oda GA, Chiesa JJ, Friesen WO, Golombek
DA (2012) Forced desynchronization of activity
rhythms in a model of chronic jet lag in mice. J Biol
Rhythms. 27:59-69 (Abstract)
(Full Text)
2. Oda GA, Friesen WO (2011) Modeling Two-Oscillator
Circadian Systems Entrained by Two Environmental Cycles. PLoS
ONE 6(8): e23895. Epub 2011 Aug 19. (Full
Text)
3. Humphrey JAC, Chen J, Iwasaki T, Friesen WO (2010)
Corrections to the theory and the optimal line in the swimming diagram of
Taylor (1952). J. R. Soc. Interface 7: 1243-1246 (Full
Text)
4. Schwartz MD, Wotus C, Liu
T, Friesen WO, Borjigin J, Oda
GA, de la Iglesia HO (2009) Dissociation of circadian and light
inhibition of melatonin release through forced desynchronization
in the rat. Proc Natl Acad Sci USA, 106:17540-5 (Full Text)
5. Chen Z, Zheng M, Friesen
WO, Iwasaki T (2008) Multivariable harmonic balance analysis of the neuronal
oscillator for leech swimming. J Comput Neurosci. 25:583-606 (Full
text)
6. Zheng M, Friesen WO, Iwasaki T (2007) Systems-level
modeling of neuronal circuits for leech swimming. J Comput Neurosci 22:21-38 (Full
Text)
7. Levy WB, Sangrey TD,
Friesen WO, Crotty P (2007)
Reply to Jurisic and Bezanilla’s
Letter to the Editor. J Neurophysiol 96:960
8. Zheng M, Iwasaki T, Friesen WO (2004) Systems approach to
modeling the neuronal CPG for leech swimming. Engineering in Medicine and Biology Society Conference Proceedings 1:703-706 (Full
Text)
9. Zheng M, Iwasaki T, Friesen WO (2004) Systems approach to
modeling the neuronal CPG for leech swimming. Conf Proc IEEE Eng Med Biol Soc. 1:703-6 (Full
Text)
10. Sangrey TD, Friesen WO, Levy WB (2004) Analysis of the
Optimal Channel Density of the Squid Giant Axon Using a Re-parameterized
Hodgkin-Huxley Model. J Neurophysiol 91:2541-50 (Full
Text)
11. Oda GA, Friesen WO (2002) A Model for “Splitting” of
Running-Wheel Activity in Hamsters. J Biol Rhythms
17:76-88 (Full
Text)
12. Friesen WO, Fleissner G, Fleissner G (2001) Role of feedback loops in the scorpion
circadian system. Neurocomputing 38-40:607-614
13. Oda GA, Menaker M, Friesen WO
(2000) Modeling the dual pacemaker system of the tau mutant hamster. J Biol Rhythms 15:246-264 (Full
Text)
14. Wolpert SX, Friesen WO (2000) On the parametric stability
of a central pattern generator Neurocomputing
32:603-608
15. Wolpert SX, Friesen WO, Laffely A
(2000) Silicon model of the Hirudo swim oscillator.
IEEE Eng
Med Biol 19 (1):64-75
16. Friesen, WO, Cheek TR, McGuinness OM, Moreton RB, Berridge MJ (1995)
Analysis of calcium fertilization transients in mouse oocytes. In
Quantitative Neuroendocrinology, vol 28, Johnson ML
and Veldius JD (eds.), New York: Academic Press,
388-423
17. Friesen WO, Block GD, Hocker
CG (1993) Formal approaches to understanding biological oscillators. Annu Rev Physiol 55:661-81 (Full
Text)
18. Friesen WO, Block GD (1984) What
is a biological oscillator? Am J Physiol
246:R847-R851 (Full
Text)
19. Block GD, McMahon DG, Wallace S, Friesen, WO (1984)
Cellular analysis of the Bulla ocular circadian pacemaker system. J Comp Physiol A 155:365-378 (Abstract)
20. Friesen WO (1980) Models, modeling and the leech
swimming rhythm. Behavioral and Brain Sciences 3:546
21. Friesen WO, Wyman RJ (1980) Analysis of Drosophila
motor neuron activity patterns with neural analogs. Biol
Cybernetics 38:41-50 (Abstract)
Top of page | Books | Computer programs | Leech neurobiology | Reviews | Modeling, comments, and miscellany | Lobster cardiac ganglion physiology| Cardiovascular physiology | Technical
Papers on lobster cardiac ganglion physiology
- Krausz HI, Friesen WO (1977) The
analysis of nonlinear synaptic transmission. J Gen Physiol
70:243-265 (Full Text)
- Krausz HI, Friesen WO (1975) Identification of
discrete input nonlinear systems using Poisson impulse trains. In:
Proceedings of the First symposium on testing and identification of
nonlinear systems. McCann G, Marmarelis P (eds) Calif Inst Tech, Pasadena, pp 125-146
- Friesen WO (1975) Antifacilitation
and facilitation in the cardiac ganglion of the spiny lobster Panulirus interruptus.
J Comp Physiol 101:207-224 (Full Text)
- Friesen WO (1975) Synaptic interactions in the
cardiac ganglion of the spiny lobster Panulirus
interruptus. J Comp Physiol
101:191-205 (Full Text)
- Friesen WO (1975) Physiological anatomy and
burst pattern in the cardiac ganglion of the spiny lobster Panulirus interruptus.
J Comp Physiol 101:173-189 (Full Text)
Papers on cardiovascular
physiology
- Ayotte B, Friesen WO, Rosenhamer
GJ, McIlroy MB (1973) A new method of
measuring pulmonary diffusing capacity for oxygen in patients with
diffuse lung disease. Am Rev Resp Dis
108:587-592
- Friesen WO, Rosenhamer, GJ, McIlroy,
MB (1972) Ear oximeter calibration using
alveolar PO measurements. Scan J Clin Lab
Invest 29:37-43 (Full Text)
- Rosenhamer GJ, Friesen, WO, McIlroy
MB (1971) A bloodless method for measurement of diffusing capacity of
the lungs for oxygen. J Appl Physiol 30:603-610 (Full Text)
- Weil JV,
Byrne-Quinn E, Sodal IE, Friesen WO, Underhill
B, Filley GF, Grover RF (1970) Hypoxic ventilatory drive in normal man. J Clin Invest 49:1061-1072 (Full Text)
Technical
- Wolpert SX, Friesen WO, Laffely A (2000)
Silicon model of the Hirudo swim oscillator.
IEEE Eng Med Biol 19
(1):64-75
- Friesen WO, Brodfuehrer
PD (1984) Identification of neurons in the leech through local ionic
manipulations. J Exp Biol
113:455-460 (Full
Text)
- Mitchell CE, Friesen WO (1981) A neuromime system for neural circuit analysis. Biol.
Cybernetics 40:127-137 (Abstract)
- Friesen WO, Stent GS (1978) Multichannel audio
monitor for detecting electrical signals. Rev Sci
Instrum 49:1691-1693 (Full Text)
- Friesen WO, McIlroy
MB (1970) Rapidly responding oxygen electrode
for respiratory gas sampling. J Appl Physiol 29:258-259 (Full
Text)
Top of page | Books
| Computer programs
| Leech neurobiology
| Reviews | Modeling, comments, and
miscellany | Lobster cardiac ganglion physiology| Cardiovascular physiology | Technical
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