Publications

Owen's Papers | Barbie's Papers

2019

I. Kucharska, P. Ding, K. K. Zadrozny, R. A. Dick, M. F. Summers, B. K. Ganser-Pornillos, O. Pornillos (2019) “Biochemical reconstitution of HIV-1 assembly and maturation,” J Virol, In press (Pubmed)

K. A. Skorupka, M. D. Roganowicz, D. E. Christensen, Y. Wan, O. Pornillos, B. K. Ganser-Pornillos (2019) “Hierarchical assembly governs TRIM5α recognition of HIV-1 and retroviral capsids,” Sci Adv 5, eaaw3631 (Pubmed) (PMC6881174) (EMDB: EMD-20562) (EMDB: EMD-20563) (EMDB: EMD-20564) (EMDB: EMD-20565) (EMDB: EMD-20574)

T. Kueck, L. M. Bloyet, E. Cassella, T. Zang, F. Schmidt, V. Brusic, G. Tekes, O. Pornillos, S. P. J. Whelan, P. D. Bieniasz (2019) “Vesicular stomatitis virus transcription is inhibited by TRIM69 in the interferon-induced antiviral state,” J Virol 93, e01372-19 (Pubmed) (PMC6880163)

B. K. Ganser-Pornillos, O. Pornillos (2019) “Restriction of HIV-1 and other retroviruses by TRIM5,” Nat Rev Microbiol 17, 546-556 (Pubmed) (PMC6858284)

O. Pornillos, B. K. Ganser-Pornillos (2019) “Maturation of retroviruses,” Curr Opin Virol 36, 47-55 (Pubmed) (PMC6730672)

M. Stevens, B. Franke, K. A. Skorupka, D. S. Cafiso, O. Pornillos, O. Mayans, D. G. Norman (2019) “Exploration of the TRIM fold of MuRF1 using EPR reveals a canonical antiparallel structure, extended COS-box,” J Mol Biol 431, 2900-2909 (Pubmed) (PMC6599887)

2018

W. I. Sundquist, O. Pornillos (2018) “Retrovirus restriction by TRIM5α: RINGside at a cage fight,” Cell Host Microbe 24, 751-753 (Pubmed) (PMC6464375)

J. G. Sanchez, K. M. J. Sparrer, C. Chiang, R. A. Reis, J. J. Chiang, M. A. Zurenski, Y. Wan, M. U. Gack, O. Pornillos (2018) “TRIM25 binds RNA to modulate anti-viral defense,” J Mol Biol 430, 5280-5293 (Pubmed) (PMC6289755)

R. A. Dick, K. K. Zadrozny, C. Xu, F. K. M. Schur, T. D. Lysson, C. L. Ricana, J. M. Wagner, J. R. Perilla, B. K. Ganser-Pornillos, M. C. Johnson, O. Pornillos, V. M. Vogt (2018) “Inositol phosphates are assembly co-factors for HIV-1,” Nature 560, 509-512 (Pubmed) (PMC6242333) (PDB: 6BHR) (PDB: 6BHS) (PDB: 6BHT)

C. Buffone, A. Martinez-Lopez, T. Fricke, S. Opp, M. Severgnini, I. Cifola, L. Petiti, S. Frabetti, K. Skorupka, K. K. Zadrozny, B. K. Ganser-Pornillos, O. Pornillos, F. Di Nunzio, F. Diaz-Griffero (2018) “Nup153 unlocks the nuclear pore complex for HIV-1 nuclear translocation in non-dividing cells,” J Virol 92, e00648-18 (Pubmed) (PMC6146805) (PDB: 5TSV) (PDB: 5TSX)

J. M. Wagner, D. E. Christensen, A. Bhattacharya, D. M. Dawidziak, M. D. Roganowicz, Y. Wan, R. A. Pumroy, B. Demeler, D. N. Ivanov, B. K. Ganser-Pornillos, W. I. Sundquist, O. Pornillos (2018) “General model for retroviral capsid pattern recognition by TRIM5 proteins,” J Virol 92, e01563-17 (Pubmed) (PMC5790955) (PDB: 5VA4)

2017

M. D. Roganowicz, S. Komurlu, S. Mukherjee, J. Plewka, S. L. Alam, K. A. Skorupka, Y. Wan, D. Dawidowski, D. S. Cafiso, B. K. Ganser-Pornillos, E. M. Campbell, O. Pornillos (2017) “TRIM5α SPRY/coiled-coil interactions optimize avid retroviral capsid recognition,” PLoS Pathog 13, e1006686 (Pubmed) (PMC5667893)

S. T. Yang, A. J. B. Kreutzberger, V. Kiessling, B. K. Ganser-Pornillos, J. M. White, L. K. Tamm (2017) “HIV virions sense plasma membrane heterogeneity for cell entry,” Sci Adv 28, e1700338 (Pubmed) (PMC5489272)

K. M. J. Sparrer, S. Gableske, M. A. Zurenski, Z. M. Parker, F. Full, G. J. Baumgart, J. Kato, G. Pacheco-Rodriguez, C. Liang, O. Pornillos, J. Moss, M. Vaughan, M. U. Gack (2017) “TRIM23 mediates virus-induced autophagy via activation of TBK1,” Nat Microbiol 2, 1543-1557 (Pubmed) (PMC5658249)

D. M. Dawidziak, J. G. Sanchez, J. M. Wagner, B. K. Ganser-Pornillos, O. Pornillos (2017) “Structure, catalytic activation of the TRIM23 RING E3 ubiquitin ligase,” Proteins 85, 1957-1961 (Pubmed) (PMC5638660) (PDB: 5VZV) (PDB: 5VZW)

P. Ł. Janczyk, K. A. Skorupka, J. G. Tooley, D. R. Matson, C. A. Kestner, T. West, O. Pornillos, P. T. Stukenberg (2017) “Mechanism of Ska recruitment by Ndc80 complexes to kinetochores,” Dev Cell 41, 438-449 (Pubmed) (PMC5926205)

2016

M. J. Bayro, B. K. Ganser-Pornillos, K. K. Zadrozny, M. Yeager, R. Tycko (2016) “Helical conformation in the CA-SP1 junction of the immature HIV-1 lattice determined from solid-state NMR of virus-like particles,” J Am Chem Soc 138, 12029-12032 (Pubmed) (PMC5636003)

J. G. Sanchez, J. J. Chiang, K. M. Sparrer, S. L. Alam, M. Chi, M. D. Roganowicz, B. Sankaran, M. U. Gack, O. Pornillos (2016) “Mechanism of TRIM25 catalytic activation in the antiviral RIG-I pathway,” Cell Rep 16, 1315-1325 (Pubmed) (PMC5076470) (PDB: 5EYA)

J. M. Wagner, K. K. Zadrozny, J. Chrustowicz, M. D. Purdy, M. Yeager, B. K. Ganser-Pornillos, O. Pornillos (2016) “Crystal structure of an HIV assembly, maturation switch,” eLife 5, e17063 (Pubmed) (PMC4946879) (PDB: 5I4T)

J. M. Wagner, M. Roganowicz, K. Skorupka, S. L. Alam, D. E. Christensen, G. L. Doss, Y. Wan, G. A. Frank, B. K. Ganser-Pornillos, W. I. Sundquist, O. Pornillos (2016) “Mechanism of B-box 2 domain-mediated higher-order assembly of the retroviral restriction factor TRIM5α,” eLife 5, e16309 (Pubmed) (PMC4936894) (PDB: 5EIU) (PDB: 5F7T) (PDB: 5IEA)

Y.-L. Li, V. Chandrasekaran, S. D. Carter, C. L. Woodward, D. Christensen, K. A. Dryden, O. Pornillos, M. Yeager, B. K. Ganser-Pornillos, G. J. Jensen, W. I. Sundquist (2016) “Primate TRIM5 proteins form hexagonal nets on HIV-1 capsids,” eLife 5, e16269 (Pubmed) (PMC4936896)

J. M. Grime, J. F. Dama, B. K. Ganser-Pornillos, C. L. Woodward, G. J. Jensen, M. Yeager, G. A. Voth (2016) “Coarse-grained simulation reveals key features of HIV-1 capsid self-assembly,” Nat Commun 7, 11568 (Pubmed) (PMC4869257)

2015

A. T. Gres, K. A. Kirby, V. N. KewalRamani, J. J. Tanner, O. Pornillos, S. G. Sarafianos (2015) “X-ray crystal structures of native HIV-1 capsid protein reveal conformational variability,” Science 349, 99-103 (Pubmed)

2014

A. Bhattacharya, S. L. Alam, T. Fricke, K. Zadrozny, J. Sedzicki, A. B. Taylor, B. Demeler, O. Pornillos, B. K. Ganser-Pornillos, F. Diaz-Griffero, D. N. Ivanov, M. Yeager (2014) “Structural basis of HIV-1 capsid recognition by PF74, CPSF6,” Proc Natl Acad Sci USA 111, 18625-18630 (Pubmed) (PDB: 4QNB)

J. G. Sanchez, K. Okreglicka, V. Chandrasekaran, J. M. Welker, W. I. Sundquist, O. Pornillos (2014) “The tripartite motif coiled-coil is an elongated antiparallel hairpin dimer,” Proc Natl Acad Sci USA 111, 2494-2499 (Pubmed) (PDB: 4LTB)

2013

M. Yeager, K. A. Dryden, B. K. Ganser-Pornillos (2013) “Lipid monolayer, sparse matrix screening for growing two-dimensional crystals for electron crystallography: methods, examples,” Methods Mol Biol 955, 527-537 (Pubmed)

2012

B. K. Ganser-Pornillos, M. Yeager, O. Pornillos (2012) “Assembly, maturation of HIV,” Adv Exp Med Biol 726, 441-465 (Pubmed)

2011

O. Pornillos, B. K. Ganser-Pornillos, M. Yeager (2011) “Atomic-level modelling of the HIV capsid,” Nature 469, 424-427 (Pubmed) (PDB: 3P05) (PDB: 3P0A)

B. K. Ganser-Pornillos, V. Chandrasekaran, O. Pornillos, J. G. Sodroski, W. I. Sundquist, M. Yeager (2011) “Hexagonal assembly of a restricting Trim5α protein,” Proc Natl Acad Sci USA 108, 534-539 (Pubmed)

2010

O. Pornillos, B. K. Ganser-Pornillos, S. Banumathi, Y. Hua, M. Yeager (2010) “Disulfide bond stabilization of the hexameric capsomer of human immunodeficiency virus,” J Mol Biol 401, 985-995 (Pubmed) (PDB: 3MGE)

D. Zhu, J. Hensel, R. Hilgraf, M. Abbasian, O. Pornillos, G. Deyanat-Yazdi, X. H. Hua, S. Cox (2010) “Inhibition of protein kinase CK2 expression, activity blocks tumor cell growth in vitro,” Mol Cell Biochem 333, 159-167 (Pubmed)

2009

O. Pornillos, B. K. Ganser-Pornillos, B. N. Kelly, Y. Hua, F. G. Whitby, C. D. Stout, W. I. Sundquist, C. P. Hill, M. Yeager (2009) “X-ray structures of the hexameric building block of the HIV capsid,” Cell 137, 1282-1292 (Pubmed) (PDB: 3GV2) (PDB: 3H4E) (PDB: 3H47)

2008

B. K. Ganser-Pornillos, M. Yeager, W. I. Sundquist (2008) “The structural biology of HIV assembly,” Curr Opin Struct Biol 18, 203-217 (Pubmed)

2007

Y.-J. Chen, O. Pornillos, S. Lieu, C. Ma, A. P. Chen, G. Chang (2007) “X-ray structure of EmrE supports dual topology model,” Proc Natl Acad Sci USA 104, 18999-19004 (Pubmed) (PDB: 3B5D) (PDB: 3B61) (PDB: 3B62)

B. K. Ganser-Pornillos, A. Cheng, M. Yeager (2007) “Structure of full-length HIV-1 CA: a model for the mature capsid lattice,” Cell 131, 70-79 (Pubmed) (PDB: 3DIK)

M. A. Hanson, A. Brooun, K. A. Baker, V. P. Jaakola, C. Roth, E. Y. Chien, A. Alexandrov, J. Velasquez, L. Davis, M. Griffith, K. Moy, B. K. Ganser-Pornillos, Y. Hua, P. Kuhn, S. Ellis, M. Yeager, R. C. Stevens (2007) “Profiling of membrane protein variants in a baculovirus system by coupling cell-surface detection with small-scale parallel expression,” Protein Expr Purif 56, 85-92 (Pubmed)

Z. Zhang, C. Ma, O. Pornillos, X. Xiu, G. Chang, M. H. Saier Jr (2007) “Functional characterization of the heterooligomeric EbrAB multidrug efflux transporter of Bacillus subtilis,” Biochemistry 46, 5218-5225 (Pubmed)

2006

O. Pornillos, G. Chang (2006) “Inverted repeat domains in membrane proteins,” FEBS Lett 580, 358-362 (Pubmed)

2005

O. Pornillos, Y.-J. Chen, A. P. Chen, G. Chang (2005) “X-ray structure of the EmrE multidrug transporter in complex with a substrate,” Science 310, 1950-1953. Retraction: G. Chang, C. B. Roth, C. L. Reyes, O. Pornillos, Y.-J. Chen, A. P. Chen (2006) Science 314, 1875

J. Benjamin, B. K. Ganser-Pornillos, W. F. Tivol, W. I. Sundquist, G. J. Jensen (2005) “Three-dimensional structure of HIV-1 virus-like particles by electron cryotomography,” J Mol Biol 346, 577-588 (Pubmed)

2004

B. K. Ganser-Pornillos, U. K. von Schwedler, K. M. Stray, C. Aiken, W. I. Sundquist (2004) “Assembly properties of the human immunodeficiency virus type 1 CA protein,” J Virol 78, 2545-2552 (Pubmed)

2003

O. Pornillos, D. S. Higginson, K. M. Stray, R. D. Fisher, J. E. Garrus, M. Payne, H. E. Wang, S. G. Morham, W. I. Sundquist (2003) “HIV Gag mimics the Tsg101-recruiting activity of the human Hrs protein,” J Cell Biol 162, 425-434 (Pubmed)

B. K. Ganser, A. Cheng, W. I. Sundquist, M. Yeager (2003) “Three-dimensional structure of the M-MuLV CA protein on a lipid monolayer: a general model for retroviral capsid assembly,” EMBO J 22, 2886-2892 (Pubmed)

B. K. Ganser (2003) Retroviral capsid assembly, Ph.D. Thesis, University of Utah

2002

O. Pornillos, J. E. Garrus, W. I. Sundquist (2002) “Mechanisms of enveloped RNA virus budding,” Trends Cell Biol 12, 569-579 (Pubmed)

O. Pornillos, S. L. Alam, D. R. Davis, W. I. Sundquist (2002) “Structure of the Tsg101 UEV domain in complex with the PTAP motif of the HIV-1 p6 protein,” Nat Struct Biol 9, 812-817 (Pubmed) (PDB: 1M4P) (PDB: 1M4Q)

O. Pornillos (2002) Ligand interactions of the HIV-1 Gag p6 domain, Ph.D. Thesis, University of Utah

O. Pornillos, S. L. Alam, R. L. Rich, D. G. Myszka, D. R. Davis, W. I. Sundquist (2002) “Structure, functional interactions of the Tsg101 UEV domain,” EMBO J 21, 2397-2406 (Pubmed) (PDB: 1KPP) (PDB: 1KPQ)

2001

J. E. Garrus, U. K. von Schwedler, O. Pornillos, S. G. Morham, K. H. Zavitz, H. E. Wang, D. A. Wettstein, K. M. Stray, M. Côté, R. L. Rich, D. G. Myszka, W. I. Sundquist (2001) “Tsg101, the vacuolar protein sorting pathway are essential for HIV-1 budding,” Cell 107, 55-65 (Pubmed)

Y. Jenkins, O. Pornillos, R. L. Rich, D. G. Myszka, W. I. Sundquist, M. H. Malim (2001) “Biochemical analyses of the interactions between human immunodeficiency virus type 1 Vpr, p6Gag,” J Virol 75, 10537-10542 (Pubmed)

1999

B. K. Ganser, S. Li, V. Y. Klishko, J. T. Finch, W. I. Sundquist (1999) “Assembly, analysis of conical models for the HIV-1 core,” Science 283, 80-83 (Pubmed)

D. B. Stierle, A. A. Stierle, B. K. Ganser (1999) “Isolation of two highly methylated polyketide derivatives from a yew-associated Penicillium species,” J Nat Prod 62, 1147-1150 (Pubmed)

1997

D. B. Stierle, A. A. Stierle, B. Ganser (1997) “New phomopsolides from a Penicillium sp,” J Nat Prod 60, 1207-1209 (Pubmed)