The vision of biologically inspired systems has tremendously impacted materials and sensing paradigms, but challenges remain towards independently localizing and tracking disparate nanoscale biochemical events. Our group specializes in applying pulsed (us-ns) and radio frequency (10 kHz – 100 MHz) electric fields within micro/nanofluidic devices for spatial manipulation and temporal analysis of biosystems. Utilizing such fields, dipoles can be selectively induced onto particular regions of biological cells depending on their electrophysiology, onto nanostructures depending on their dielectric properties, and onto biomolecules depending on their conformation to enable their frequency-selective bio-manipulation, tracking and sensing.
"Quantitative dielectrophoretic tracking for characterization and separation of persistent subpopulations of Cryptosporidium Parvum”, Y. –H. Su, M. Tsegaye, W. Varhue, K. T. Liao+, L. Abebe, J. A. Smith, R. L. Guerrant, N. S. Swami*; Analyst (2014) 139, 66-73.Cover Article & listed as: “Hot Article”. Link
“Disinfection action of electrostatic versus steric-stabilized silver nanoparticles on E. Coli”, E. Fauss, E. MacCusppie, V. Carver, J. A. Smith, N. S. Swami*, Colloids & Surfaces B: Biointerfaces (2014), 113, 77-84. Link
“Enhanced penetration of fluoride particles into bovine enamel through combining AC electro-osmosis with dielectrophoresis”, C. Ivanoff, N.S. Swami, T. Hottel, F. Godoy-Garcia. Electrophoresis (2013) DOI: 10.1002/elps.201300206