Meta-Analysis of Diagnostic Tests


This is a web page of the paper

"Repeated-measures modeling improved comparison of diagnostic tests in meta-analysis of dependent studies"

 by Mir Said Siadaty, MS MD*, John T. Philbrick, MD**, Steven W. Heim, MD MSPH***, and Joel M. Schectman, MD MPH**.
* Division of Biostatistics and Epidemiology, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
** Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
*** Department of Family Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
J Clin Epidemiol. 2004 Jul;57(7):698-711. PMID: 15358397 for PubMed


Contents
  1. Document on "Relationship between Moses et al SROC Method and the Logistic Regression" in PDF.
  2. Document on “Relationship between Diagnostic Odds Ratio (DOR) and Receiver Operating Characteristic (ROC) curve” in PDF.
  3. Document on “Relationship between Diagnostic Odds Ratio (DOR) and the Predictive Values (PPV and NPV)” in PDF.
  4. Code written for R to convert DOR to other performance measures. They are Positive Predictive Value (PPV), Negative Predictive Value (NPV), Likelihood Ratio For Abnormal Test (LRab), Likelihood Ratio For Normal Test (LRnr), Pre Test Odds,  Post Test Odds Of Abnormal Test, Post Test Odds Of Normal Test,  Post Test Probability Of Abnormal Test, Post Test Probability Of Normal Test, in text format.
  5. Code written for R to convert DOR and plot ROC and area-under-curve (AUC), in text format.
  6. Code written for R to convert DOR and to plot PPV and NPV, in text format.
  7. How to run the R codes on my computer.
  8. "Steps of a Complete Meta-Analysis" illustrating a comprehensive step-by-step analysis of a real dataset, including presentation and interpretation of different graphs, tables, and exhibits, in PDF.
  9. These helps are available.
  10. Here is a copy of the data file for the DVT example we used for demonstration in the paper, in MS Excel format, in comma-separated (.csv) text format.
  11. This paper has been published utilizing the method of meta-analysis proposed in this webpage "D-dimer testing for deep venous thrombosis: a metaanalysis". Heim SW, Schectman JM, Siadaty MS, Philbrick JT. Clin Chem. 2004 Jul;50(7):1136-47. Epub 2004 May 13. Here is PubMed link (PMID: 15142977). Here is a link to PDF version.
  12. This is our continuation work, on the topic of meta-analysis of diagnostic tests. We have intorduced proportional odds ratio POR model.

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Reprint requests and correspondence:
Mir S Siadaty, MS MD
UVA School of Medicine, DHES,
Box 800717
Charlottesville, VA 22908
Phone (434) 982 4436
Fax (434) 924 8437
mirSiadaty@virginia.edu


Go to the University of Virginia home page
Maintained by MirSiadaty@virginia.edu
Last Modified: 15 September 04

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