Publications:

RECENT PUBLICATIONS

Gregory, S.M., E. Harada, B. Liang, S. Delos, J.M. White, and L.K. Tamm. 2011. Structure and function of the complete internal fusion loop from ebolavirus GP2. Proc. Nat'l. Acad. Sci. 108:11211-11216.

Avinoam, O., K. Fridman, C. Valansi, I. Abutbul, T. Zeev-Ben-Mordehai, U.E. Maurer, A. Sapir, D. Danino, K. Grünewald, J.M. White, and B. Podbilewicz. 2011. Conserved Eukaryotic Fusofens can Fuse Viral Envelopes to Cells. Science. 332: 589-592.

Dube, D., K.L. Schornberg, C.J. Shoemaker, S.E. Delos, T.S. Stantchev, K.A. Clouse, C.C. Broder, and J.M. White. 2010. Cell adhesion dependent membrane trafficking of a binding partner for the ebolavirus glycoprotein is a determinant of viral entry. Proc. Nat'l. Acad. Sci. 107:16637-42.

Mire, C.E., J.M. White, and M.A. Whitt. 2010. A spatio-temporal analysis of matrix protein and nucleocapsid trafficking during vesicular stomatitis virus uncoating. Plos Path. 6: e1000994.

Wei, S., G. Xu, L.C. Bridges, P. Williams, J.M. White, and D. DeSimone. 2010. ADAM13 induces cranial neural crest by cleaving class B ephrins and regulating Wnt signaling. Dev. Cell. 19:345-352.

Wei,S, C.A. Whittaker, G. Xu. A. Shah, J.M. White, and D. DeSimone. 2010. Conservation and divergence of ADAM family proteins in the Xenopus genome. BMC Evol. Biol. 10:211-223.

Delos, S.E., La, B., Gilmartin, A., and J.M. White. 2010. Studies of the "chain reversal regions" of the avian sarcoma/leukosis virus (ASLV) and ebolavirus fusion proteins: analogous residues are important, and a His residue unique to EnvA affects the pH dependence of ASLV entry. J. Virol. 84: 5687-5694.

Schornberg, K.L., C.J. Shoemaker, D. Dube, M.Y. Abshire, S.E. Delos, A.H. Bouton, and J.M. White. 2009. a5b1 Integrin controls ebolavirus entry by regulating endosomal cathepsins. Proc. Nat'l. Acad. Sci. 106:8003-8008.

Dube, D., M.B. Brecher, S.E. Delos, S.C. Rose, E.W. Park, K.L. Schornberg, J.H. Kuhn, and J.M. White. 2009. The primed ebolavirus glycoprotein (19-Kilodalton GP1,2): Sequence and residues critical for host cell binding. J. Virol. 83:2883-2891.

Mire, C. E., D. Dube, S.E. Delos, J.M. White, and M.A. Whitt. 2009. Glycoprotein-Dependent Acidification of Vesicular Stomatitis Virus Enhances Release of Matrix Protein. J. Virol. 83:12139-12150.

Dube, D., K. Schornberg, T. Stantchev, M. Bonaparte, S.E. Delos, A.H. Bouton, C. Broder, and J.M. White. 2008. Cell adhesion promotes Ebola virus glycoprotein-mediated binding and infection. J. Virol. 82:7238-7242.

Delos, S. E., M. B. Brecher, Z. Chen, D. C. Melder, M. J. Federspiel, and J. M. White. 2008. Cysteines Flanking the Internal Fusion Peptide Are Required for the Avian Sarcoma/Leukosis Virus Glycoprotein to Mediate the Lipid Mixing Stage of Fusion with High Efficiency. J Virol. 82:3131-3134.

White, J.M., S.E. Delos, M. Brecher, and K. Schornberg. 2008. Structures and mechanisms of viral membrane fusion proteins: multiple variations on a common theme. Crit. Reviews Biochem. and Molec. Biol., 43:189-219.

SELECTED EARLIER PUBLICATIONS

White, J.M. 2007. The first family of cell-cell fusion. Dev. Cell, 12:667-668.

Harris, A., Cardone, G., Winkler, D.C., Heymann, J.B., Brecher, M., White, J.M., and Steven, A.C. 2006. Influenza virus pleiomorphy characterized by cryo-electron tomography. Proc. Nat'l. Acad. Sci. 103: 19123-19127

Schornberg, K., S. Matsuyama, K. Kabsch, S.E. Delos,, A.H. Bouton, and J.M. White. 2006. Role of endosomal cathepsins in entry mediated by the Ebola virus glycoprotein. J. Virol., 80: 4174-4178.

Lai, A.L., H. Park, J.M. White, and L.K. Tamm. 2006. Fusion peptide of influenza hemagglutinin requires a fixed-angle boomerang structure for function. J. Biol. Chem 281:5760-5770.

Huang, J., L.C. Bridges, and J.M. White. 2005. Selective Modulation of Integrin-mediated Cell Migration by Distinct ADAM Family Members. Mol Biol Cell. 16:4982-4991.

Earp, L.J., S.E. Delos, H.E. Park, and J.M. White. 2005. The many mechanisms of viral membrane fusion proteins. Curr Top Microbiol Immunol. 285:25-66.

Delos, S.E., J.A. Godby, and J.M. White. 2005. Receptor-Induced Conformational Changes in the SU Subunit of the Avian Sarcoma/Leukosis Virus A Envelope Protein: Implications for Fusion Activation. J Virol. 79:3488-99.

White, J.M., and J.D. Castle. 2005. Searching for the silver lining. Nat Struct Mol Biol. 12:382-4.

Matsuyama, S., S.E. Delos, and J.M. White. 2004. Sequential roles of receptor binding and low pH in forming prehairpin and hairpin conformations of a retroviral envelope glycoprotein. J. Virol.78:8201-8209.

Park, H., J. Gruenke, and J.M. White. 2003. Leash in the groove mechanism of membrane fusion. Nat. Struct. Biol. 10:1048-1053

White, J. M. 2003. ADAMs: modulators of cell–cell and cell–matrix interactions. Curr. Op. Cell Biol. 15:598-606

Earp, L.E., S.E. Delos, R.C. Netter, P. Bates, and J.M. White. 2003. The avian retrovirus ASLV-A reaches the lipid mixing stage of fusion at neutral pH. J.Virol., 77:3058-3066.

Gruenke, J.A., Armstrong, R.T., Newcomb, W.W., Brown, J.C. and White, J.M., 2002. New insights into the spring-loaded conformational change of influenza hemagglutinin, J. Virol. 76: 4456-4466.

Smith, K.M., A. Gaultier, H. Cousin, D. Alfandara, J.M. White, and D. DeSimone. 2002. The Cysteine-Rich Domain Regulates ADAM Protease Function in vivo. J. Cell Biol., 159:893-902.

Alfandari, D., Cousin, H., Gaultier, A., Smith, K., White, J.M. Darribere, T. and DeSimone, D.W. 2001. Xenopus ADAM 13 is a mettaloprotease required for cranial neural crest-cell migration. Curr. Biol., 11, 918-930

Takahashi, Y., D. Bigler, Y. Ito, and J.M. White. 2001. Sequence-specific interactions between the disintegrin domain of mouse ADAM 3 and murine eggs: role of the integrin associated proteins CD9, CD81 and CD98. Mol. Biol. Cell. 12:809-820.

White, J.M. and M.D. Rose. 2001. Yeast mating: Getting close to membrane merger. Curr. Biol. 11:R16-R20.

Moss, M.L., J.M. White, M.H. Lambert, and R.C. Andrews. 2001. TACE and other ADAM proteases as targets for drug discovery. Drug Disc. Today, 6:417-426.

Delos, S.E., J.M. Gilbert, and J.M. White. 2000. The central proline of an internal viral fusion peptide serves two important roles. J. Virol. 74:1686-1693.

Bigler, D., Y. Takahashi, M.S. Chen, E.A.C. Almeida, L. Osbourne, and J.M. White. 2000. Sequence-specific interaction between the disintegrin domain of mouse ADAM 2 (fertilin and murine eggs; Role of the ?6 integrin subunit. J. Biol. Chem., 275: 11576-11584.

Delos, S.E., and J.M. White. 2000. Critical role for the cysteines flanking the internal fusion peptide of avian sarcoma/leukosis virus envelope glycoprotein. J. Virol. 74: 9738-9741.

Armstrong, R.T., A. Kushnir, and J.M. White. 2000. The transmembrane domain of influenza hemagglutinin exhibits a stringent length requirement to promote the hemifusion to fusion transition. J. Cell Biol. 151: 425-438.

Chen, M.S., Almeida, E.A.C., A.-P.J. Huovila, Y. Takahashi, L.M. Shaw, A.M. Mercurio, and J.M. White 1999. Evidence that distinct states of the integrin a6b1 interact with laminin and an ADAM. J. Cell Biol. 144:549-561.

Qiao, H., R.T. Armstrong, G.B. Melikyan, F.S. Cohen, and J.M. White. 1999. A specific point mutant at position 1 of the influenza hemagglutinin fusion peptide displays a hemifusion phenotype. Mol. Biol. Cell 10:2759-2769.

Chen, M.S., K.S. Tung, S.A. Coonrod, Y. Takahashi, D. Bigler, Y. Yamashita, P.W. Kincade, J.C. Herr, and J.M. White. 1999. Role of the integrin-associated protein CD9 in binding between sperm ADAM 2 and the egg integrin a6b1: implications for murine fertilization. Proc. Nat’l Acad. Sci. 96:11830-11835.

Qiao, H., S. Pelletier, L. Hoffman, R.T. Armstrong, J. Hacker, and J.M. White. 1998. Specific single or double proline substitutions in the "spring-loaded" coiled-coil region of the influenza hemagglutinin impair or abolish membrane fusion activity. J. Cell Biol., 141:1335-1347

Wolfsberg, T.G. and J.M. White. 1998. ADAM metalloproteinases. In Handbook of Proteolytic Enzymes, Eds. A.J. Barrett, N.D., Rawlings and J.F. Woessner. pp. 1310-1313.

Black, R.A. and J.M. White. 1998. ADAMs: Focus on the protease domain. Curr. Op. Cell Biol., 10:654-659.

Alfandari, D., T.G. Wolfsberg, J.M. White, and D.W. DeSimone. 1997. ADAM 13: A novel ADAM expressed in somatic mesoderm and neural crest cells during Xenopus laevis development. Dev. Biol. 182:314-330.

Hoffman, L.R., I.D. Kuntz, and J.M. White. 1997. Structure-based identification of an inducer of the low pH conformational change in the influenza hemagglutinin: irreversible inhibition of infectivity. J. Virol. 71:8808-8820.

Hernandez, L.D., R.R. Peters, S.E. Delos, J.A.T. Young, D.A. Agard, and J.M. White. 1997. Activation of a retroviral membrane fusion protein: soluble receptor induced liposome binding of the ALSV envelope glycoprotein. J. Cell Biol., 139: 1455-1464.

Danieli, T., S.L. Pelletier, Y.I. Henis and J.M. White. 1996. Membrane fusion mediated by the influenza virus hemagglutinin requires the concerted action of at least three hemagglutinin trimers. J. Cell Biol. 133:559-569.

Hernandez, L.D., L.R. Hoffman, T.G. Wolfsberg, and J.M. White. 1996. Virus-cell and cell-cell fusion. Annu. Rev. Cell Devel. Biol. 12:627-661.

Wolfsberg, T.G. and J.M. White. 1996. ADAMs in fertilization and development. Dev. Biol. 180: 389-401.

Snell, W.J. and J.M. White 1996. The molecules of mammalian fertilization. Cell. 85:629-637.

Wolfsberg, T.G., P.D. Straight, R.L. Gerena, A.J. Huovila, P. Primakoff, D.G. Myles, and J.M. White. 1995. ADAM, a widely distributed and developmentally regulated gene family encoding membrane proteins with a disintegrin and metalloprotease domain. 1995. Devel. Biol. 169:378-383.

Almeida, E.A.C., A.J. Huovila, A.E. Sutherland, L.E. Stephens, P.G., P.G. Calarco, L.M. Shaw, A.M. Mercurio, A. Sonnenberg, P. Primakoff, D.G. Myles, and J.M. White. 1995. Mouse egg integrin a6b1 functions as a sperm receptor. Cell. 81:1095-1104.

Gilbert, J.M., L.D. Hernandez, J.W. Balliet, P. Bates, and J.M. White. 1995. Receptor-induced conformational changes in the subgroup A avian leukosis and sarcoma virus envelope glycoprotein. J. Virol. 69:7410-7415.

Wolfsberg, T.G. et al. 1995. ADAM, a novel family of membrane proteins containing a disintegrin and metalloprotease domain: multipotential functions in cell-cell and cell-matrix interactions. J. Cell Biol. 131:275-278.

White, J.M. 1995. Membrane fusion: the influenza paradigm. CSHSQB:60:581-588.

Kemble, G.W., T. Danieli, and J.M. White. 1994. Lipid-anchored influenza hemagglutinin promotes hemifusion, not complete fusion. Cell. 76: 383-391.

Gilbert, J.M., P. Bates, H.E. Varmus, and J.M. White. 1994. The receptor for subgroup A avian leukosis-sarcoma viruses binds to subgroup A but not subgroup C envelope glycoprotein. J. Virol. 68:5623-5628.

Bodian, D.L., R.B. Yamasaki, R.L. Buswell, J.F. Stearns, J.M. White and I.D. Kuntz. 1993. Inhibition of the fusion inducing conformational change of influenza hemagglutinin by benzoquinones and hydroquinones. Biochem. 32:2967-2978.

Wolfsberg, T.G., J.F. Bazan, C.P. Blobel, D.G. Myles, P. Primakoff and J.M. White. 1993. The precursor region of a protein active in sperm-egg fusion contains a metalloprotease domain and a disintegrin domain: Structural, functional, and evolutionary implications. Proc. Nat'l. Acad. Sci. USA. 90:10783-10787.

White, J.M. 1993. Integrins as virus receptors. Curr. Biol. 3:596-599

Blobel, C.P, T.G. Wolfsberg, C.W. Turck, D.G. Myles, P. Primakoff and J.M. White. 1992. A potential fusion peptide and an integrin ligand domain in a protein active in sperm-egg fusion. Nature 356:248-252.

Glenn, J.S., J.A. Watson, C.M. Havel and J.M. White. 1992. Identification of a prenylation site in delta virus large antigen. Science 256:1331-1333.

Blobel, C.P. and J.M. White. 1992. Structure, function, and evolutionary relationship of proteins containing a disintegrin domain. Curr. Opinions Cell Biol. 4:760-765.

White, J.M. 1992. Membrane fusion. Science 258:917-924.

Blobel, C., D. Myles, P. Primakoff and J.M. White. 1990. Proteolytic processing of a protein involved in sperm-egg fusion correlates with acquisition of fertilization competence. J. Cell Biol. 111:69-78.

Weiss, C., J. Levy, and J. White. 1990. Oligomeric organization of gp120 on infectious Human immunodeficiency virus Type 1 particles. J. Virol., 64:5674-5677

Spruce, A.E., A. Iwata, J.M. White, and W. Almers. 1989. Patch clamp studies of single cell fusion events mediated by a viral fusion protein. Nature 342:555-558.

White, J.M. and D. Littman. 1989. Viral receptors of the immunoglobulin superfamily. Cell 56:725-728.

White, J. and I. Wilson. 1987. Anti-peptide antibodies detect steps in a protein conformational change: low pH activation of the hemagglutinin of influenza virus. J. Cell Biol. 105:2887-2896.