Publications:

RECENT PUBLICATIONS

Dube, D., K. Schornberg, T. Stantchev, M. Bonaparte, S.E. Delos, A.H. Bouton, C. Broder, and J.M. White. 2008. Cell adhesion promotes Ebola virus glycoprotein-mediated binding and infection. J. Virol. 82:7238-7242.

Delos, S. E., M. B. Brecher, Z. Chen, D. C. Melder, M. J. Federspiel, and J. M. White. 2008. Cysteines Flanking the Internal Fusion Peptide Are Required for the Avian Sarcoma/Leukosis Virus Glycoprotein to Mediate the Lipid Mixing Stage of Fusion with High Efficiency. J Virol. 82:3131-3134.

White, J.M., S.E. Delos, M. Brecher, and K. Schornberg. 2008. Structures and mechanisms of viral membrane fusion proteins: multiple variations on a common theme. Crit. Reviews Biochem. and Molec. Biol., 43:189-219.

White, J.M. 2007. The first family of cell-cell fusion. Dev. Cell, 12:667-668.

Harris, A., Cardone, G., Winkler, D.C., Heymann, J.B., Brecher, M., White, J.M., and Steven, A.C. 2006. Influenza virus pleiomorphy characterized by cryo-electron tomography. Proc. Nat'l. Acad. Sci. 103: 19123-19127

Schornberg, K., S. Matsuyama, K. Kabsch, S.E. Delos,, A.H. Bouton, and J.M. White. 2006. Role of endosomal cathepsins in entry mediated by the Ebola virus glycoprotein. J. Virol., 80: 4174-4178.

Lai, A.L., H. Park, J.M. White, and L.K. Tamm. 2006. Fusion peptide of influenza hemagglutinin requires a fixed-angle boomerang structure for function. J. Biol. Chem 281:5760-5770.

SELECTED EARLIER PUBLICATIONS

Huang, J., L.C. Bridges, and J.M. White. 2005. Selective Modulation of Integrin-mediated Cell Migration by Distinct ADAM Family Members. Mol Biol Cell. 16:4982-4991.

Earp, L.J., S.E. Delos, H.E. Park, and J.M. White. 2005. The many mechanisms of viral membrane fusion proteins. Curr Top Microbiol Immunol. 285:25-66.

Delos, S.E., J.A. Godby, and J.M. White. 2005. Receptor-Induced Conformational Changes in the SU Subunit of the Avian Sarcoma/Leukosis Virus A Envelope Protein: Implications for Fusion Activation. J Virol. 79:3488-99.

White, J.M., and J.D. Castle. 2005. Searching for the silver lining. Nat Struct Mol Biol. 12:382-4.

Matsuyama, S., S.E. Delos, and J.M. White. 2004. Sequential roles of receptor binding and low pH in forming prehairpin and hairpin conformations of a retroviral envelope glycoprotein. J. Virol.78:8201-8209.

Park, H., J. Gruenke, and J.M. White. 2003. Leash in the groove mechanism of membrane fusion. Nat. Struct. Biol. 10:1048-1053

White, J. M. 2003. ADAMs: modulators of cell–cell and cell–matrix interactions. Curr. Op. Cell Biol. 15:598-606

Earp, L.E., S.E. Delos, R.C. Netter, P. Bates, and J.M. White. 2003. The avian retrovirus ASLV-A reaches the lipid mixing stage of fusion at neutral pH. J.Virol., 77:3058-3066.

Gruenke, J.A., Armstrong, R.T., Newcomb, W.W., Brown, J.C. and White, J.M., 2002. New insights into the spring-loaded conformational change of influenza hemagglutinin, J. Virol. 76: 4456-4466.

Smith, K.M., A. Gaultier, H. Cousin, D. Alfandara, J.M. White, and D. DeSimone. 2002. The Cysteine-Rich Domain Regulates ADAM Protease Function in vivo. J. Cell Biol., 159:893-902.

Alfandari, D., Cousin, H., Gaultier, A., Smith, K., White, J.M. Darribere, T. and DeSimone, D.W. 2001. Xenopus ADAM 13 is a mettaloprotease required for cranial neural crest-cell migration. Curr. Biol., 11, 918-930

Takahashi, Y., D. Bigler, Y. Ito, and J.M. White. 2001. Sequence-specific interactions between the disintegrin domain of mouse ADAM 3 and murine eggs: role of the integrin associated proteins CD9, CD81 and CD98. Mol. Biol. Cell. 12:809-820.

White, J.M. and M.D. Rose. 2001. Yeast mating: Getting close to membrane merger. Curr. Biol. 11:R16-R20.

Moss, M.L., J.M. White, M.H. Lambert, and R.C. Andrews. 2001. TACE and other ADAM proteases as targets for drug discovery. Drug Disc. Today, 6:417-426.

Delos, S.E., J.M. Gilbert, and J.M. White. 2000. The central proline of an internal viral fusion peptide serves two important roles. J. Virol. 74:1686-1693.

Bigler, D., Y. Takahashi, M.S. Chen, E.A.C. Almeida, L. Osbourne, and J.M. White. 2000. Sequence-specific interaction between the disintegrin domain of mouse ADAM 2 (fertilin and murine eggs; Role of the ?6 integrin subunit. J. Biol. Chem., 275: 11576-11584.

Delos, S.E., and J.M. White. 2000. Critical role for the cysteines flanking the internal fusion peptide of avian sarcoma/leukosis virus envelope glycoprotein. J. Virol. 74: 9738-9741.

Armstrong, R.T., A. Kushnir, and J.M. White. 2000. The transmembrane domain of influenza hemagglutinin exhibits a stringent length requirement to promote the hemifusion to fusion transition. J. Cell Biol. 151: 425-438.

Chen, M.S., Almeida, E.A.C., A.-P.J. Huovila, Y. Takahashi, L.M. Shaw, A.M. Mercurio, and J.M. White 1999. Evidence that distinct states of the integrin a6b1 interact with laminin and an ADAM. J. Cell Biol. 144:549-561.

Qiao, H., R.T. Armstrong, G.B. Melikyan, F.S. Cohen, and J.M. White. 1999. A specific point mutant at position 1 of the influenza hemagglutinin fusion peptide displays a hemifusion phenotype. Mol. Biol. Cell 10:2759-2769.

Chen, M.S., K.S. Tung, S.A. Coonrod, Y. Takahashi, D. Bigler, Y. Yamashita, P.W. Kincade, J.C. Herr, and J.M. White. 1999. Role of the integrin-associated protein CD9 in binding between sperm ADAM 2 and the egg integrin a6b1: implications for murine fertilization. Proc. Nat’l Acad. Sci. 96:11830-11835.

Qiao, H., S. Pelletier, L. Hoffman, R.T. Armstrong, J. Hacker, and J.M. White. 1998. Specific single or double proline substitutions in the "spring-loaded" coiled-coil region of the influenza hemagglutinin impair or abolish membrane fusion activity. J. Cell Biol., 141:1335-1347

Wolfsberg, T.G. and J.M. White. 1998. ADAM metalloproteinases. In Handbook of Proteolytic Enzymes, Eds. A.J. Barrett, N.D., Rawlings and J.F. Woessner. pp. 1310-1313.

Black, R.A. and J.M. White. 1998. ADAMs: Focus on the protease domain. Curr. Op. Cell Biol., 10:654-659.

Alfandari, D., T.G. Wolfsberg, J.M. White, and D.W. DeSimone. 1997. ADAM 13: A novel ADAM expressed in somatic mesoderm and neural crest cells during Xenopus laevis development. Dev. Biol. 182:314-330.

Hoffman, L.R., I.D. Kuntz, and J.M. White. 1997. Structure-based identification of an inducer of the low pH conformational change in the influenza hemagglutinin: irreversible inhibition of infectivity. J. Virol. 71:8808-8820.

Hernandez, L.D., R.R. Peters, S.E. Delos, J.A.T. Young, D.A. Agard, and J.M. White. 1997. Activation of a retroviral membrane fusion protein: soluble receptor induced liposome binding of the ALSV envelope glycoprotein. J. Cell Biol., 139: 1455-1464.

Danieli, T., S.L. Pelletier, Y.I. Henis and J.M. White. 1996. Membrane fusion mediated by the influenza virus hemagglutinin requires the concerted action of at least three hemagglutinin trimers. J. Cell Biol. 133:559-569.

Hernandez, L.D., L.R. Hoffman, T.G. Wolfsberg, and J.M. White. 1996. Virus-cell and cell-cell fusion. Annu. Rev. Cell Devel. Biol. 12:627-661.

Wolfsberg, T.G. and J.M. White. 1996. ADAMs in fertilization and development. Dev. Biol. 180: 389-401.

Snell, W.J. and J.M. White 1996. The molecules of mammalian fertilization. Cell. 85:629-637.

Wolfsberg, T.G., P.D. Straight, R.L. Gerena, A.J. Huovila, P. Primakoff, D.G. Myles, and J.M. White. 1995. ADAM, a widely distributed and developmentally regulated gene family encoding membrane proteins with a disintegrin and metalloprotease domain. 1995. Devel. Biol. 169:378-383.

Almeida, E.A.C., A.J. Huovila, A.E. Sutherland, L.E. Stephens, P.G., P.G. Calarco, L.M. Shaw, A.M. Mercurio, A. Sonnenberg, P. Primakoff, D.G. Myles, and J.M. White. 1995. Mouse egg integrin a6b1 functions as a sperm receptor. Cell. 81:1095-1104.

Gilbert, J.M., L.D. Hernandez, J.W. Balliet, P. Bates, and J.M. White. 1995. Receptor-induced conformational changes in the subgroup A avian leukosis and sarcoma virus envelope glycoprotein. J. Virol. 69:7410-7415.

Wolfsberg, T.G. et al. 1995. ADAM, a novel family of membrane proteins containing a disintegrin and metalloprotease domain: multipotential functions in cell-cell and cell-matrix interactions. J. Cell Biol. 131:275-278.

White, J.M. 1995. Membrane fusion: the influenza paradigm. CSHSQB:60:581-588.

Kemble, G.W., T. Danieli, and J.M. White. 1994. Lipid-anchored influenza hemagglutinin promotes hemifusion, not complete fusion. Cell. 76: 383-391.

Gilbert, J.M., P. Bates, H.E. Varmus, and J.M. White. 1994. The receptor for subgroup A avian leukosis-sarcoma viruses binds to subgroup A but not subgroup C envelope glycoprotein. J. Virol. 68:5623-5628.

Bodian, D.L., R.B. Yamasaki, R.L. Buswell, J.F. Stearns, J.M. White and I.D. Kuntz. 1993. Inhibition of the fusion inducing conformational change of influenza hemagglutinin by benzoquinones and hydroquinones. Biochem. 32:2967-2978.

Wolfsberg, T.G., J.F. Bazan, C.P. Blobel, D.G. Myles, P. Primakoff and J.M. White. 1993. The precursor region of a protein active in sperm-egg fusion contains a metalloprotease domain and a disintegrin domain: Structural, functional, and evolutionary implications. Proc. Nat'l. Acad. Sci. USA. 90:10783-10787.

White, J.M. 1993. Integrins as virus receptors. Curr. Biol. 3:596-599

Blobel, C.P, T.G. Wolfsberg, C.W. Turck, D.G. Myles, P. Primakoff and J.M. White. 1992. A potential fusion peptide and an integrin ligand domain in a protein active in sperm-egg fusion. Nature 356:248-252.

Glenn, J.S., J.A. Watson, C.M. Havel and J.M. White. 1992. Identification of a prenylation site in delta virus large antigen. Science 256:1331-1333.

Blobel, C.P. and J.M. White. 1992. Structure, function, and evolutionary relationship of proteins containing a disintegrin domain. Curr. Opinions Cell Biol. 4:760-765.

White, J.M. 1992. Membrane fusion. Science 258:917-924.

Blobel, C., D. Myles, P. Primakoff and J.M. White. 1990. Proteolytic processing of a protein involved in sperm-egg fusion correlates with acquisition of fertilization competence. J. Cell Biol. 111:69-78.

Weiss, C., J. Levy, and J. White. 1990. Oligomeric organization of gp120 on infectious Human immunodeficiency virus Type 1 particles. J. Virol., 64:5674-5677

Spruce, A.E., A. Iwata, J.M. White, and W. Almers. 1989. Patch clamp studies of single cell fusion events mediated by a viral fusion protein. Nature 342:555-558.

White, J.M. and D. Littman. 1989. Viral receptors of the immunoglobulin superfamily. Cell 56:725-728.

White, J. and I. Wilson. 1987. Anti-peptide antibodies detect steps in a protein conformational change: low pH activation of the hemagglutinin of influenza virus. J. Cell Biol. 105:2887-2896.