Publications

  1. Synthesis of Dimetallaazacyclobutenes via Reaction of Polynuclear Heteroaromatic Compounds with Triruthenium Dodecacarbonyl: Reactivity and Structural Elucidation. R.H. Fish, T.-J. Kim, J.L. Stewart, J.H. Bushweller, R.K. Rosen, and J.W. Dupon (1986) Organometallics 5, 2193-2198.

  2. Enzymes of the Shikimate Pathway - Mechanistic Inferences from Synthesis of Intermediates and Inhibitors. Bartlett, P.A., Satake, K., Fassler, A., Nyfeler, R., Alberg, D.G., Chouinard, P.M., Maitra, U., Lauhon, C.T., Johnson, C.R., Nakagawa, Y., Hediger, M.E., Bushweller, J.H. (1988) Biochemistry 27, 3078.

  3. Synthesis of Cis and Trans-1-Methylcyclohexane-1,4-diols and Their 4- Hemisuccinate Esters. J.H. Bushweller, L. Anzalone, and T.A. Spencer (1989) Synthetic Communications 19, 745-754.

  4. Sulfoxide Analogues of Dihydro- and Tetrahydroprephenate as Inhibitors of Prephenate Dehydratase. J.H. Bushweller and P.A. Bartlett (1989) J. Org. Chem. 54, 2404-2409.

  5. Investigation of an Octapeptide Inhibitor of E. coli Ribonuclotide Reductase by Transferred Nuclear Overhauser Effect Spectroscopy. J.H. Bushweller and P.A. Bartlett (1991) Biochemistry 30, 8144-8151. [View PubMed Listing]

  6. Sequence-specific 1H N.M.R. Assignments and Determination of the Three-dimensional Structure of Reduced E. coli Glutaredoxin. P. Sodano, T. Xia, J.H. Bushweller, O. Björnberg, A. Holmgren, M. Billeter, and K. Wüthrich, (1991) J. Mol. Biol. 221, 1311-1324. [View PubMed Listing]

  7. NMR Structure of Oxidized E. coli Glutaredoxin: Comparison with Reduced E. coli Glutaredoxin and Functionally Related Proteins. T. Xia, J.H. Bushweller, P. Sodano, M. Billeter, O. Björnberg, A. Holmgren, and K. Wüthrich (1992) Protein Sci. 1, 310-321. [View PubMed Listing]

  8. Structural and Functional Characterization of the Mutant E. coli Glutaredoxin(C14->S) and Its Mixed Disulfide with Glutathione. J.H. Bushweller, F. Åslund, K. Wüthrich, and A. Holmgren (1992) Biochemistry, 31, 9288-9293. [View PubMed Listing]

  9. 3D 13C-15N-Heteronuclear Two-spin Coherence Spectroscopy for Polypeptide Backbone Assignments in 13C-15N-doubly-labelled Proteins. T. Szyperski, G. Wider, J.H. Bushweller, and K. Wüthrich (1993) J. Biomol. NMR 3, 127-132. [View PubMed Listing]

  10. Reduced Dimensionality in Triple-resonance Experiments. T. Szyperski, G. Wider, J.H. Bushweller and K. Wüthrich (1993) JACS 115, 9307-9308.

  11. Biosynthetic 15N and 13C Isotope-labelling of Glutathione in the Mixed Disulfide with E. coli Glutaredoxin Documented by Sequence-specific NMR Assignments. J.H. Bushweller, A. Holmgren and K. Wüthrich (1993) Eur. J. Biochem. 218, 327-334. [View PubMed Listing]

  12. The NMR Solution Structure of the Mixed Disulfide Between E. coli Glutaredoxin(C14->S) and Glutathione. J.H. Bushweller, M. Billeter, A. Holmgren and K. Wüthrich (1994) J. Mol. Biol. 235, 1585-1597. [View PubMed Listing]

  13. Stereodynamics of 9,11-Diphenyl-10-azatetracyclo[6.3.0.0.4,110.5,9]undecanes. Highly Restricted Nitrogen Inversion and Isolated Phenyl Rotation. X-ray Crystallographic, Dynamic NMR, and Molecular Mechanics Studies. Gordon W. Gribble, Frank L. Switzer, John H. Bushweller, John G. Jewett, Jay H. Brown, Jessica L. Dion, C. Hackett Bushweller, Marianne P. Byrn, Charles E. Strouse (1995) JOC 61, 4319. [View PubMed Listing]

  14. Biochemical and Biophysical Properties of the CBFa2(AML1) DNA- Binding Domain. Barbara E. Crute, Amy Lewis, Zining Wu, John H. Bushweller and Nancy A. Speck (1996) J. Biol. Chem. 271, 26251-26260. [View PubMed Listing]

  15. The Core-Binding Factor (CBF) b Subunit Is Essential For CBFa2 (AML1) Function In Vivo. Qing Wang, Terryl Stacy, Janelle D. Miller, Amy F. Lewis, Ting-Lei Gu, Xuemei Huang, John H. Bushweller, Jean-Christopher Bories, Frederick W. Alt, Michael Binder, Miguel Marin-Padilla, Arlene H. Sharpe and Nancy A. Speck (1996) Cell 87, 697-708. [View PubMed Listing]

  16. Complete 1H, 13C, and 15N NMR Resonance Assignments and Secondary Structure of Human Glutaredoxin in the Fully Reduced Form. Chaohong Sun, Arne Holmgren and John H. Bushweller (1997) Protein Sci. 6, 383-390. [View PubMed Listing]

  17. Comparison of Backbone Dynamics of Reduced and Oxidized E. coli Glutaredoxin-1 Using 15N NMR Relaxation Measurements. John J. Kelley, Thomas Caputo, Steven F. Eaton, Thomas M. Laue and John H. Bushweller, (1997) Biochemistry 36, 5029-5044. [View PubMed Listing]

  18. Preparation, Characterization, and Complete Heteronuclear NMR Resonance Assignments of the Glutaredoxin(C14S)-Ribonucleotide Reductase B1 736-761 (C754S) Mixed Disulfide. Marcelo Berardi, Cynthia L. Pendred and John H. Bushweller (1998)Biochemistry 37, 5849-5857. [View PubMed Listing]

  19. The NMR Solution Structure of Fully Reduced Human Glutaredoxin. Chaohong Sun, Marcelo Berardi and John H. Bushweller (1998)J. Mol. Biol. 280, 687-701. [View PubMed Listing]

  20. Complete Heteronuclear NMR Resonance Assignments for Vaccinia Glutaredoxin in the Fully Reduced Form. John J. Kelley and John H. Bushweller, (1998) J. Biomol. NMR 12(2), 353-355. [View PubMed Listing]

  21. Complete Heteronuclear NMR Resonance Assignments and Secondary Structure of Core-Binding Factor b (1-141). Xuemei Huang, Nancy A. Speck and John H. Bushweller (1998) J. Biomol. NMR 12(3), 459-460. [View PubMed Listing]

  22. A PCR-Based Method for Large Scale Synthesis of Uniformly 13C/15N- labeled DNA Duplexes. Xian Chen, S.V. Santhana Mariappan, John J. Kelley III, John H. Bushweller, E. Morton Bradbury, and Goutam Gupta (1998) FEBS Letters 436, 372-6. [View PubMed Listing]

  23. Solution Structure of Core Binding Factor B and Map of the CBFA Binding Site. Xuemei Huang, Jeff Peng, Nancy A. Speck and John H. Bushweller (1999) Nature Structural Biology, 6(7), 624-627. [View PubMed Listing]

  24. Binding Specificity and Mechanistic Insights into Glutaredoxin Protein Disulfide Reduction. Marcelo Berardi and John H. Bushweller (1999) J. Mol. Biol. 292(1), 151-161. [View PubMed Listing]

  25. The Ig Fold of the Core Binding Factor a Runt Domain is a Member of a Family of Structurally and Functionally Related Ig Fold DNA Binding Domains. Marcelo Berardi, Chaohong Sun, Michael Zehr, Frits Abildgard, Jeff Peng, Nancy A. Speck and John H. Bushweller (1999) Structure, 7, 1247-1256. [View PubMed Listing]

  26. Haploinsufficiency of CBFA2 (AML1) causes familial thrombocytopenia with propensity to develop acute myelogenous leukemia (FPD/AML). WooJoo Song, Melanie Sullivan, Sarah Hutchings, Robert D. Legare, Dubravka Kufrin, Janina Ratajczak, Keiying Ma, Isabel C. Resende, Mignon Loh, Carolyn Felix, Alan Gewirtz, Carey Haworth, Cheryl Willman, Denis-Claude Roy, Lambert Busque, David Kurnit, Nancy A. Speck, John H. Bushweller, Fred Li, Katheleen Gardiner, Mortimer Poncz, John M. Maris, and D. Gary Gilliland (1999) Nature Genetics, 23(2), 166-175. [View PubMed Listing]

  27. The NOESY jigsaw: automated protein secondary structure and main-chain assignment from sparse unassigned NMR data. Chris Bailey-Kellogg, Alex Widge, John Kelley, Marcelo J. Berardi, John H. Bushweller, and Bruce R. Donald (2000) J. Comp. Biol., 7(3-4), 537-558. [View PubMed Listing]

  28. Biophysical Characterization of Interactions Between the Core Binding Factor a and b Subunits and DNA. Barbara E. Crute, Yen-Yee Tang, John J. Kelley, Xuemei Huang, Jiangli Yan, Jianxia Shi, Kari L. Hartman, Thomas M. Laue, Nancy A. Speck and John H. Bushweller(2000) FEBS Letters, 470, 167-172. [View PubMed Listing]

  29. CBF - A Biophysical Perspective John H. Bushweller(2000) Seminars in Cell and Developmental Biology, 11, 377-382. [View PubMed Listing]

  30. Energetic and functional contributions of residues in the Core Binding Factor B (CBFB) Subunit to Heterodimerization with CBFA. Yen-Yee Tang, Jianxia Shi, Lina Zhang, Amy Davis, Jeronimo Bravo, Alan Warren, Nancy A. Speck, and John H. Bushweller (2000) J. Biol. Chem., 275, 39579-39588. [View PubMed Listing]

  31. Structure of outer membrane protein A transmembrane domain by NMR spectroscopy Ashish Arora, Frits Abildgaard, John H. Bushweller, and Lukas K. Tamm (2001) Nat. Struc. Biol., 8, 334-338. [View PubMed Listing]

  32. An Optimized PCR-Based Procedure for Production of 13C/15N-Labeled DNA Jiangli Yan and John H. Bushweller (2001) BBRC, 284, 295-300. [View PubMed Listing]

  33. Membrane Structure and Fusion-Triggering Conformational Change of the Fusion Domain from Influenza Hemagglutinin Xing Han, John H. Bushweller, David S. Cafiso, and Lukas K. Tamm (2001) Nat. Struc. Biol., 8, 715-720. [View PubMed Listing]

  34. MQ-HCN-based Pulse Sequences for the Measurement of C1'-H1', C1'-N, H1'-N,C1'-C2', H1'-C2', C6/8-H6/8, C6/8-N, H6/8-N, C6-C5, H6-C5 Dipolar Couplings in 13C,15N-labeled DNA (and RNA) Jiangli Yan, Takeshi Corpora, Padmanava Pradhan, and John H. Bushweller (2001) J. Biomol. NMR, 22, 9-20. [View PubMed Listing]

  35. Altered Affinity of CBFB­SMMHC, Product of the Inv(16), for Runx1 Explains its Dominant Negative Activity and Role in Leukemogenesis. Stephen M. Lukasik, Lina Zhang, Takeshi Corpora, Sarah Tomanicek, Yuanhong Li, Mondira Kundu, Kari Hartman, P. Paul Liu, Thomas M. Laue, Rodney L. Biltonen, Nancy A. Speck, and John H. Bushweller. (2002) Nature Structural Biology, 9, 674-679. [View PubMed Listing]

  36. Assignment of 1H, 13C and 15N resonances of the N-terminal microtubule-binding domain of human doublecortin. Cierpicki T, Kim MH, Otlewski J, Derewenda ZS, Bushweller JH. (2003) J. Biomol. NMR, 25, 81-82. [View PubMed Listing]

  37. The DCX-domain tandems of doublecortin and doublecortin-like kinase. Kim MH, Cierpicki T, Derewenda U, Krowarsch D, Feng Y, Devedjiev Y, Dauter Z, Walsh CA, Otlewski J,Bushweller JH, Derewenda ZS. (2003) Nature Structural Biology, 10, 324-333. [View PubMed Listing]

  38. Structural and functional characterization of Runx1, CBFbeta, and CBFbeta-SMMHC. Zhang L, Lukasik SM, Speck NA, Bushweller JH. (2003) Blood Cells Mol Dis., 30, 147-156. [View PubMed Listing]

  39. Hepatoma derived growth factor is a nuclear targeted mitogen. Allen D. Everett and John H. Bushweller. (2003) Current Drug Targets, 4, 367-371. [View PubMed Listing]

  40. Mutagenesis of the Runt domain defines two energetic hotspots for heterodimerization with the core binding factor beta subunit. Zhang L, Li Z, Yan J, Pradhan P, Corpora T, Cheney MD, Bravo J, Warren AJ, Bushweller JH, Speck NA. (2003) J. Biol. Chem., 278, 33097-33104. [View PubMed Listing]

  41. Energetic contribution of residues in the Runx1 Runt domain to DNA binding. Li Z, Yan J, Matheny CJ, Corpora T, Bravo J, Warren AJ, Bushweller JH, Speck NA. (2003) J. Biol. Chem., 278, 33088-33096. [View PubMed Listing]

  42. Structure, dynamics and function of the outer membrane protein A and influenza hemagglutinin fusion domain in detergent micelles by solution NMR Tamm, LK, Abildgaard, F, Arorra, A, Blad, H., and Bushweller, JH. (2003) FEBS Letters, 555, 139-143. [View PubMed Listing]

  43. Synthesis and evalutation of substituted 4-aryloxy- and 4-arylsulfanyl- phenyl-2-aminothiazoles as inhibitors of human breast cancer cell proliferation. Gorczynski, MJ, Mooberyy, SL, Bushweller, JH, and Brown ML. Bushweller JH, Speck NA. (2004) Bio. Med. Chem. Lett., 12, 1029-1036. [View PubMed Listing]

  44. CBFb allosterically regulates the Runx1 Runt domain via a dynamic conformational equlibrium. Yan, J, Liu, Y, Lukasik, SM, Speck, NA, and Bushweller JH. (2004) Nat. Struc. Mol. Biol., 11, 901-906. [View PubMed Listing]

  45. Charged gels as orienting media for measurment of residual dipolar couplings in soluble and integral membrane proteins. Cierpicki, T. and Bushweller JH. (2004) J. Am. Chem. Soc., 126, 16259-16266. [View PubMed Listing]

  46. Probing the supramodular architecture of a multidomain protein by NMR: the solution structure of syntenin. Cierpicki, T., Bushweller, J.H., and Derewenda, Z. (2005) Structure, 13, 1-9. [View PubMed Listing]

  47. Membrane Structures of the Hemi-Fusion-Inducing Fusion Peptide Mutant G1S and the Fusion-Blocking Mutant G1V of Influenza Hemagglutinin Suggest A Mechanism for Pore Opening in Membrane Fusion. Li,Y., Han, X., Lai, A.L., Bushweller, J.H.,Cafiso, D.S., and Tamm, L.K. (2005) J. Virology, 79, 12065-76. [View PubMed Listing]

  48. Allosteric Activation of Protein Phosphatase 2C by Mn2+-D-Chiro-Inositol-Galactosamine, a Putative Mediator-Mimetic of Insulin Action. Brautigan D. L., Brown, M., Grindrod, S., Chinigo, G., Kruszewski, A., Lukasik, S., Bushweller, J. H., Horal, M., Keller, S., Tamura, S., Heimark, D. B., Price, J., Larner, A. N., and Larner (2005) Biochemistry, 44, 11067-11073. [View PubMed Listing]

  49. High-Resolution NMR Structure and Functional Characterization of the PWWP Domain from Hepatoma Derived Growth Factor (HDGF). Lukasik, S,M., Cierpicki, T., Borloz, M., Grembecka, J., Everett, A., and Bushweller, J,H. (2006) Protein Science, 15, 314-323. [View PubMed Listing]

  50. The binding of the PDZ tandem of syntenin to target proteins. Grembecka, J.,Cierpicki, T., Devedjiev, Y., Derewenda, U., Kang, B.S., Bushweller, J.H., and Derewenda, Z.S. (2006) Biochemistry, 45, 3674-83. [View PubMed Listing]

  51. Site-Directed Parallel Spin-Labeling and Paramagnetic Relaxation Enhancement in Structure Determination of Membrane Proteins by Solution NMR Spectroscopy. Liang, B., Bushweller, J.H., and Tamm, L.K. (2006) JACS, 128, 6947-6951. [View PubMed Listing]

  52. The tetramer structure of the Nervy homology two domain (NHR2) is critical for AML1/ETO’s activity. Liu, Y., Cheney, M.D., Gaudet, J.J., Chruszcz, M., Lukasik, S.M., Sugiyama, D., Lary, J., Cole, J., Dauter, Z., Minor, M., Speck, N.A., and Bushweller, J.H. (2006) Cancer Cell, 9, 249-260. [View PubMed Listing]

  53. The DC-module of doublecortin: dynamics, domain boundaries and functional implications. Cierpicki, T., Kim, M.H., Cooper, D.R., Derewenda, U., Bushweller, J.H., and Derewenda, Z.S. (2006) Proteins: Structure, Function, and Bioinformatics, 64, 874-882. [View PubMed Listing]

  54. Increasing the accuracy of solution NMR structures of membrane proteins by application of residual dipolar couplings - high resolution structure of outer membrane protein A. Cierpicki, T., Liang, B., Tamm, L.K., and Bushweller, J.H. (2006) JACS, 128, 6947-6951. [View PubMed Listing]

  55. A mutation in the S-switch region of the Runt domain alters the dynamics of an allosteric network responsible for CBFß regulation. Li, Z., Lukasik, S.M., Liu, Y., Grembecka, J., Bielnicka, I., Bushweller, J.H., and Speck, N.A. (2006) J. Mol. Biol., 364, 1073-1083. [View PubMed Listing]

  56. Disease mutations in RUNX1 and RUNX2 create nonfunctional, dominant negative, or hypomorphic alleles. Matheny, C.J., Speck, M.E., Cushing, P.R., Zhou, Y., Corpora, T., Regan, M., Newman, M., Speck, C.L., Gu, T., Griffey, S.M., Bushweller, J.H., and Speck, N.A. (2007) EMBO J., 26, 1163-1175. [View PubMed Listing]

  57. Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activity. u, Y., Chen, W., Gaudet, J., Cheney, M.D., Roudaia, L., Cierpicki, T., Klet, R.C., Hartman, K., Laue, T.M., Speck, N.A., and Bushweller, J.H. (2007) Cancer Cell, 11, 483-497. [View PubMed Listing]

  58. Allosteric Inhibition of the Protein-Protein Interaction Between the Leukemia-Associated Proteins RUNX1 and CBFß. Gorczynski, M.J., Grembecka, J., Zhou, Y., Kong, Y., Roudaiya, L., Douvas, M.G., Newman, M., Bielnicka, I., Baber, G., Corpora, T., Shi, J., Sridharan, M., Lilien, R., Donald, B.R., Speck, N.A., Brown, M.L., and Bushweller, J.H.. (2007) Chemistry & Biology, 14, 1186-1197. [View PubMed Listing]

  59. MLL protects CpG clusters from methylation within the Hoxa9 gene, maintaining transcript expression. Erfurth FE, Popovic R, Grembecka J, Cierpicki T, Theisler C, Xia ZB, Stuart T, Diaz MO, Bushweller JH, Zeleznik-Le NJ. (2008) Proc. Natl. Acad. Sci USA, 105, 7517-22. [View PubMed Listing]

  60. NMR solution structure of the integral membrane enzyme DsbB: functional insights into DsbB-catalyzed disulfide bond formation. Zhou Y, Cierpicki T, Jimenez RH, Lukasik SM, Ellena JF, Cafiso DS, Kadokura H, Beckwith J, Bushweller JH. (2008) Molecular Cell, 31, 896-908. [View PubMed Listing]

  61. CBFß is critical for AML1-ETO and TEL-AML1 activity. Liya Roudaia, Matthew D. Cheney, Ekaterina Manuylova, Wei Chen, Michelle Morrow, Sangho Park, Prabhjot Kaur, Owen Williams, John H. Bushweller, and Nancy A. Speck. (2009) Blood, 113, 3070-9. [View PubMed Listing]

  62. Structure of the AML1-ETO eTAFH domain - HEB peptide complex and its contribution to AML1-ETO activity. Sangho Park, Wei Chen, Tomasz Cierpecki, Marco Tonelli, Xiongwei Cai, Nancy A. Speck, and John H. Bushweller. (2009) Blood, 113, 3558-67. [View PubMed Listing]

  63. On the mechanism of autoinhibition of the RhoA-specific nucleotide exchange factor PDZRhoGEF. Zheng M, Cierpicki T, Momotani K, Artamonov MV, Derewenda U, Bushweller JH, Somlyo AV, Derewenda ZS. (2009) BMC Struct. Biol., 9, 36. [View PubMed Listing]

  64. The solution structure and dynamics of the DH-PH module of PDZRhoGEF in isolation and in complex with nucleotide-free RhoA. Cierpicki T, Bielnicki J, Zheng M, Gruszczyk J, Kasterka M, Petoukhov M, Zhang A, Fernandez EJ, Svergun DI, Derewenda U, Bushweller JH, Derewenda ZS. (2009) Protein Science, 18, 2067-79. [View PubMed Listing]

  65. The role of CBFß in AML1-ETO’s activity. Sangho Park, Nancy A. Speck, and John H. Bushweller. (2009) Blood, 114, 2849-50. [View PubMed Listing]

  66. Structure of the MLL CXXC domain – DNA complex and its functional role in MLL-AF9 leukemia. Tomasz Cierpicki, Laurie E. Risner, Jolanta Grembecka, Stephen M. Lukasik, Relja Popovic, Monika Omonkowska, David S. Shultis, Nancy J. Zeleznik-Le, and John H. Bushweller. (2010) Nat. Struct. Mol. Biol., 17, 62-68. [View PubMed Listing]

  67. Accelerated Leukemogenesis by Truncated CBFb-SMMHC Defectivein High-Affinity Binding with RUNX1.. Yasuhiko Kamikubo, Ling Zhao, Mark Wunderlich, Takeshi Corpora, R. Katherine Hyde, Thomas A. Paul, Mondira Kundu, Lisa Garrett, Sheila Compton, Gang Huang, Linda Wolff, Yoshiaki Ito, John Bushweller, James C. Mulloy, and P. Paul Liu. (2010) Cancer Cell, 17, 455-468. [View PubMed Listing]

  68. The PHD3 domain of MLL acts as a CYP33-regulated switch between MLL-mediated activation and repression. Sangho Park, Ute Osmers, Gayathree Raman, Rebecca H. Schwantes, Manuel O. Diaz, and John H. Bushweller. (2010) Biochemistry, 49, 6576-86. [View PubMed Listing]

  69. Structure of the AML1-ETO Nervy domain – PKA(RIIa) complex and its contribution to AML1-ETO activity. Takeshi Corpora, Liya Roudaia, Zaw Min Oo, Wei Chen, Ekaterina Manuylova, Xiongwei Cai, Michael J. Chen, Tomasz Cierpicki , Nancy A. Speck, and John H. Bushweller. (2010) J. Mol. Biol., 402, 560-77. [View PubMed Listing]

  70. Application of Fragment Based Drug Discovery to Membrane Proteins: Biophysical Identification of Ligands of the Integral Membrane Enzyme DsbB. Virginie Früh, Yunpeng Zhou, Dan Chen, Caroline Loch, Eiso AB, Yelena N. Grinkova, Herman Verheij, Stephen G, Sligar, John H. Bushweller, and Gregg Siegal. (2010) Chemistry & Biology, 17, 881-891. [View PubMed Listing]

  71. Mutation Sites for PRE Data Collection and Membrane Protein Structure Prediction. Chen H, Ji F, Olman V, Mobley CK, Liu Y, Zhou Y, Bushweller JH, Prestegard JH, Xu Y. (2011) Structure, 19, 484-95. [View PubMed Listing]

  72. MLL fusion partner AF9 is an intrinsically disordered transcriptional regulator which recruits multiple partners via coupled folding and binding. Benjamin I Leach, Aravinda Kuntimaddi, Charles R Schmidt, Tomasz Cierpicki, Stephanie A Johnson, and John H. Bushweller. (2013) Structure, 21, 176-83. [View PubMed Listing]

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