Herpes Virus Research Laboratory

University of Virginia School of Medicine

Department of Microbiology, Immunology and Cancer Biology

Jay C. Brown, Principal Investigator

Research goals: We study the replication and pathogenesis of herpes simplex virus with the idea that specific steps might constitute attractive targets for the design of novel therapeutics effective against HSV infections. Since replication of all members of the herpesvirus family share important features, new information about HSV-1 replication is expected to apply to all herpesviruses. Two herpesviruses, Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV), are known to cause cancer in humans. It is expected that research on HSV-1 replication will clarify aspects of tumorigenesis by these viruses. Specific projects underway in the laboratory are designed to examine the structure and assembly of the tegument, egress of progeny virions from the host cell, and the role of coatomer in HSV-1 replication.

The site is divided into four sections that describe: (1) background information about herpesviruses and their replication; (2) our current research, and the laboratory personnel involved in specific research projects; (3) recent results from projects on tegument disassembly, tegument structure and exit of progeny HSV-1 virions from the host cell; and (4) some relevant papers from other laboratories. All sections can be accessed by clicking the appropriate link below.

Background

Taxonomy

HSV-1 Structure

HSV-1 Genome

HSV-1 Replication

Current Studies

Projects

Recent Results

Tegument Structure

Tegument Protein UL36

 

Relevant Papers from Other Laboratories

 

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Maintained by jcb2g@virginia.edu
Last Modified: 27 July 2012