| Abstract : Differences in nasal anatomy among human subjects may cause significant differences in respiratory airflow patterns and subsequent dosimetry of inhaled gases and particles in the respiratory tract. This talk will examine the development, implementation and validation of computational fluid dynamic simulations to study inter-individual differences in nasal airflow. Streamline patterns, velocity and helicity were compared to show that inter-individual differences exist in bulk airflow patterns in the nose. This suggests that uptake of inhaled material will vary from person to person and have implications for nasal drug delivery and toxicological risk estimates. |