David Auble
APS is an adaptor that modulates receptor tyrosine kinase activity. The protein homodimerizes via an N-terminal motif that forms an unusual four helix bundle that the authors describe as consisting of two bisecting, U-shaped monomers. The overall shape is sort of like two pairs of overlapping chopsticks. Ten phenylalanine residues, five from each monomer, form an interdigitating stack. Compare the structure to that of a leucine zipper. The images here are derived from 1q2h.
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