David Auble
2. (14 points) A colleague has solved the structure of a TATA binding protein (TBP)-containing complex and is interested in your thoughts. The structure is shown below. Describe the complex. What protein features mediate the macromolecular interaction? What are the implications for TBP's DNA binding activity? Your colleague has a short attention span, so limit your response to 150 words. Write the word count at the end of your answer. You may use class notes and handouts, as well as anything on the Auble lectures web site, but no other resources. Time limit: 30 minutes. Return your answer (hard copy) to David Auble in Jordan Hall Room 6213 by 6:00 pm Wednesday, November 19.
Go to Question 1
Answer: 1tba. You can read all about it here. There were many good answers to this question; all made use of the console commands to visualize the complex in different ways to distinguish different features of the macromolecules in different ways. Answers that were vague, made guesses about the structure without actually investigating it, or contained general information from the lecture not directly relevant to the complex did not score well. A few people apparently assumed that TBP was bound to a DNA molecule in this complex, but this is not the case!
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