G. Moyle-Heyrman, R. Viswanathan, J. Widom, and D.T. Auble. Two-step Mechanism for Modifier of Transcription (Mot1) Enzyme-catalyzed Displacement of TATA-binding Protein (TBP) from DNA. J. Biol. Chem., in press.

R. Viswanathan and D.T. Auble. One Small Step for Mot1; One Giant Leap for Other Swi2/Snf2 Enzymes? BBA Gene Reg. Mech. 1809:488-496, 2011. <Access article>

P. Wollmann, S. Cui, R. Viswanathan, O. Berninghausen, M.N. Wells, M. Moldt, G. Witte, A. Butryn, P. Wendler, R. Beckmann, D.T. Auble* and K.-P. Hopfner*. Structure and mechanism of the Swi2/Snf2 remodeler Mot1 in complex with its substrate TBP. Nature 475:403-407, 2011. *co-corresponding authors
<Access article and supplement > <EcTBP structure (PDB 3OCI)> <EcMot1 NTD-TBP complex (PDB 3OC3)>

E. M. Hyland, H. Molina, K. Poorey, C. Jie, Z. Xie, J. Dai, J. Qian, S. Bekiranov, D.T. Auble, A. Pandey, and J.D. Boeke. An Evolutionarily "Young" Lysine Residue In Histone H3 Attenuates Transcriptional Output in Saccharomyces cerevisiae. Genes & Dev. 25:1306-1319, 2011. <PDF> <Table S1> <Table S2> <Table S3> <Supplemental Figures>

K. Poorey, R.O. Sprouse, M.N. Wells, R. Viswanathan, S. Bekiranov, and D.T. Auble. RNA Synthesis Precision Is Regulated by Preinitiation Complex Turnover. Genome Res. 20:1679-1688, 2010. <PDF><Supplemental Material>

S.L. Wade and D.T. Auble. The Rad23 Ubiquitin Receptor, the Proteasome and Functional Specificity in Transcriptional Control. Transcription 1:22-26, 2010. <Open-access article>

S.L. Wade, K. Poorey, S. Bekiranov, and D.T. Auble. The Snf1 kinase and proteasome-associated Rad23 regulate UV-responsive gene expression. EMBO J. 28:2919–2931, 2009. <PDF> <Supplemental Results> <List of all genes with a significant UV effect in WT cells>

R.O. Sprouse, M.N. Wells, and D.T. Auble. TATA Binding Protein Variants that Bypass the Requirement for Mot1 In Vivo. J. Biol. Chem. 284:4525-4535, 2009. <PDF> <Supplemental Results>

D. Basu, M. P. Walkiewicz, M. Frieman, R.S. Baric, D.T. Auble, and D.A. Engel. Novel influenza NS1 antagonists block replication and restore innate immune function. J. Virol. 83:1881-1891, 2009. <PDF>

D.T. Auble.  The Dynamic Personality of TATA-Binding Protein. Trends in Biochem. Sci. 34:49-52, 2009. <PDF>

R.O. Sprouse, T.S. Karpova, F. Mueller, A. Dasgupta, J.G. McNally, and D.T. Auble. Regulation of TATA-Binding Protein Dynamics in Living Yeast Cells. Proc. Nat. Acad. Sci. USA 105:13304 –13308, 2008. <PDF> <Supporting Information>

R.O. Sprouse, I. Shcherbakova, H. Cheng, E. Jamison, M. Brenowitz, and D.T. Auble. Functional and Structural Organization of Mot1 Bound to a Natural Target Promoter. J. Biol. Chem. 283:24935-24948, 2008. <PDF> <Table S1> <Figure S1> (Figure S1 is a movie.)

A. Dasgupta, R.O. Sprouse, S. French, P. Aprikian, R. Hontz, S.A. Juedes, J.S. Smith, A.L. Beyer, and D.T. Auble. Regulation of rRNA Synthesis by TATA-Binding Protein-Associated Factor Mot1. Mol. Cell. Biol. 27:2886-2896, 2007. <PDF>

R.O. Sprouse, M. Brenowitz, and D.T. Auble. Snf2/Swi2-Related ATPase Mot1 Drives Displacement of TATA-Binding Protein by Gripping DNA.  EMBO J. 25: 1492-1504, 2006. <PDF>
Supplemental data: <Figure S1> <Figure S2> <Figure S3> <Figure S4>

A. Dasgupta, S.A. Juedes, R.O. Sprouse, and D.T. Auble. Mot1-Mediated Control of Transcription Complex Assembly and Activity.  EMBO J. 24: 1717-1729, 2005.  <PDF>
Supplemental data: <Figure S1> <Figure S2> <Figure S3> <Figure S4> <Table S1>

T. Miyake, J. Reese, C. Loch, D.T. Auble, and R. Li. Genome-Wide Analysis of ARS Binding Factor 1 (Abf1p)-Mediated Transcriptional Regulation in Saccharomyces cerevisiae.  J. Biol. Chem., 279: 34865-34872, 2004.  <PDF>

K.L. Ramsey, J. J. Smith, A. Dasgupta, N. Maqani, Patrick Grant and D.T. Auble.  The NEF4 complex regulates Rad4 levels and utilizes Snf2/Swi2-related ATPase activity for nucleotide excision repair.  Mol. Cell. Biol., 24: 6362-6378, 2004.  <PDF> <Supplemental data>

A. Dasgupta,  K.L. Ramsey, J.S. Smith and D.T. Auble.  Sir Antagonist 1 (San1) is a Ubiquitin Ligase.  J. Biol. Chem., 279: 26830-26838, 2004.  <PDF>

R. P. Darst, A. Dasgupta, C. Zhu, J.-Y. Hsu, A. Vroom, T. Muldrow, and D. T. Auble.  Mot1 Regulates the DNA Binding Activity of Free TBP in an ATP-Dependent Manner. J. Biol. Chem, 278:13216-13226, 2003.  <PDF>

A. Dasgupta, R.P. Darst, K.J. Martin, C.A. Afshari, and D.T. Auble.  Mot1 Activates and Represses Transcription by Direct, ATPase-Dependent Mechanisms.  Proc. Nat. Acad. Sci. USA 99:2666-2671, 2002.  <PDF> < Supplemental data>

R.P. Darst, D. Wang, and D.T. Auble. Mot1-Catalyzed TBP-DNA Disruption: Uncoupling DNA Conformational Change and Role of Upstream DNA.  EMBO J.   20:2028-2040, 2001.  <PDF>

Y. Cang, D.T. Auble, and G. Prelich.  A New Regulatory Domain on the TATA-Binding Protein.  EMBO J. 18:6662-6671, 1999.  <PDF>

T.A. Muldrow, A.M. Campbell, P.A. Weil, and D.T. Auble.  Mot1 Can Activate Basal Transcription In Vitro by Regulating the Distribution of TBP Between Promoter and Nonpromoter Sites.  Mol. Cell. Biol. 19:2835-2845, 1999.  <PDF>

D.T. Auble, and S.M. Steggerda.  Testing for DNA Tracking by Mot1, a Snf2/Swi2 Protein Family Member.  Mol. Cell. Biol. 19:412-423, 1999. <PDF>