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•UVA Department of Biochemistry & Molecular Genetics •UVA Biomolecular Core Facility •David's lectures in BIMS/Biochemistry 503
•Auble Lab Intranet
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Research Overview We are interested in proteins that are members of the Snf2/Swi2 ATPase family. These amazing proteins utilize ATP hydrolysis to disrupt protein-DNA interactions in a wide variety of biological processes in all cells. This activity can lead to lateral displacement or ejection of proteins from DNA or reorganization of chromatin structure. Enzymes in this family play critical and conserved roles in transcription, DNA repair and recombination. Our analysis of how these enzymes function has deepened our appreciation of their roles in transcription and DNA repair, and has led us in new directions to explore how the processes of transcription and repair are regulated.
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