VASCULAR
BIOLOGY COURSE ANNOUNCEMENT
A class in Vascular
Biology will be offered Tuesday and Thursday afternoons during the Spring
Semester, 2009. The class will be
team-taught by an outstanding faculty, all of whom are experts in their fields. During the course of the semester
several opportunities will be provided for students to present material from
the literature. The presentations
will be in the form of a student debate on a controversial topic of interest in
vascular biology.
Vascular
Biology
BIMS
852 – Spring 2009
Course
Director: Brian R. Duling, PhD
brd@virginia.edu
924-9040 Tuesdays and Thursdays
1:30-3:00 Physiology Conference Room, 4th floor Jordan Hall |
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Date |
Topic |
Speaker |
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Principles of Vascular Design |
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Jan
13
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VASCULAR PATTERN FORMATION IN VIVO |
Little |
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Jan 15 |
Angiogenesis
and Microvascular Remodeling: Capillary Sprouting Dynamics |
Price |
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Jan
20
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Angiogenesis and Microvascular
Remodeling: Microvessel Maturation |
Peirce-Cottler |
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Jan22 |
Vascular
Smooth DIFFERENTIATION |
Owens |
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Jan 27 |
Tumor
Angiogenesis |
Tucker |
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Jan 29 |
Controversy in vascular biology |
Students |
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BIOLOGY OF VASCULAR CELLS |
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Feb 3 |
Endothelial
cell biology IIII – Paracrine Signaling |
Isakson |
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Feb 5 |
Endothelial
Cell Biology II - Cytoskeleton |
Helmke |
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Feb 10 |
Endothelal Cell Biology
I - Matrix |
Schwartz |
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Feb 12 |
Vascular
Smooth Muscle Cell Biology I– the contractile
process |
Somlyo, Wamhoff |
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Feb 17 |
Vascular
Smooth Muscle Cell Biology II – intracellular
signaling cascades |
Somlyo, Wamhoff |
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Feb. 19 |
Platelet
Biology |
Gear |
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Feb 24 |
Leukocyte
biology |
Ley |
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Feb 26 |
LEUKOCYTES IN INFLAMMATION |
Ley |
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Mar 3 |
Spring
Recess |
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Mar 5 |
Spring
Recess |
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Mar 10 |
Controversy in vascular biology |
Students |
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Principles of Vascular Function |
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Mar 12 |
CAPILLARY EXCHANGE AND ENDOTHELIAL CELL
PERMEABILITY |
Duling |
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Mar 17 |
VASCULAR CELL-CELL COMMUNICATION |
Isakson |
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Mar 19 |
INTRINSIC VASCULAR
CONTROL PROCESSES |
Duling |
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Mar 24 |
Controversy
in vascular biology |
Students |
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Mar 26 |
Hemodynamics
and Vascular Cell Responses |
Blackman |
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Mar 31 |
NEURAL VASCULAR CONTROL PROCESSES |
Guyenet |
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Apr 2 |
Controversy in vascular biology |
Students |
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Vascular Pathophysiology |
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April
7
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VASCULAR INFLAMMATION |
Linden |
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April 9 |
HEMOSTASIS/THROMBOSIS |
Gear |
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April 14 |
Controversy
in vascular biology |
Students |
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April 16 |
HYPERTENSION |
Carey |
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April 21 |
Experimental Biology Meetings |
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April 23 |
ATHEROSCLEROSIS |
McNamara |
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April 28 |
DIABETES |
Hedrick |
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May 2 |
Reading day |
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May 5
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Final Exam |
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May 16 |
Vascular Biology Luncheon
- The Lawn Garden Pavillion 8 - 12pm to 2pm |
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EXAMPLES
OF STUDENT TOPICS
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Athrosclerosis Vulnerable Plaque Smooth muscle growth triggers The role of the adventitia in regulating neointimal growth A role for B Lymphocytes? Are foam cells within atherosclerotic lesions
derived exclusively from macrophages? |
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ENDOTHELIUM Circulating
stem cells can give rise to either endothelial cells, or SMC within the
peripheral vasculature |
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ATHEROSCLEROSIS Atero
is the result of altered bulk phase pinocytosis not unregulated uptake of
oxid LDL by the scavenger LDL receptor. |
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ANGIOGENESIS Matrix in angiogenesis Mesenchymal origin of vessel wall cells Stimuli to angiogenesis Capillary adaptation to use Stem cells and angiogenesis |
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Bone marrow-derived SMCs and vascular disease Do bone
marrow-derived stem cells give rise to SMCs in neointimal hyperplasia. |
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neural
vascular control Receptor heterogeneity Synthetic processes NO as a transmitter Co-transmitter release Role of ATP Presynaptic
regulation |
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CLOTTING AND
THROMBOLYSIS Endothelium and hemostasis
Thrombin in hemostasis and cellular growth |
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NEUTROPHIL-ENDOTHELIAL
CELL INTERACTIONS The oxidative burst Adhesion moleculespx White cell viscosity
and resistance Addressins and the
high endothelium |
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VASCULAR INFLAMMATION Cytokines and
inflammation Autoimmunity |
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SMOOTH MUSCLE-ENDOTHELIAL CELL COMMUNICATION Gap junctions? |
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SMOOTH MUSCLE CONTRACTION Regulation
of myosin light chain phosphatase Calcium independent contractions Intracellular Ca++
stores in smooth muscle and endothelium |
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ENDOTHELIAL CELL
SIGNALING NO and wall shear
stress Endothelin and
sepsis Endothelin and
hypertension NO – cGMP
inhibitory pathway |
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