Test 123 VASCULAR
BIOLOGY COURSE ANNOUNCEMENT
A
class in Vascular Biology will be offered Tuesday and Thursday afternoons
during the Spring Semester, 2009.
The class will be team-taught by an outstanding faculty, all of whom are
experts in their fields. During
the course of the semester several opportunities will be provided for students
to present material from the literature.
The presentations will be in the form of a student debate on a
controversial topic of interest in vascular biology.
Vascular Biology
BIMS 852 – Spring
2009
Course Director: Brian R. Duling, PhD
brd@virginia.edu 924-9040 Tuesdays and
Thursdays 1:30-3:00 Physiology Conference
Room, 4th floor Jordan Hall |
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Date |
Topic |
Speaker |
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Principles of Vascular Design |
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Jan
13
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VASCULAR PATTERN FORMATION IN VIVO |
Little |
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Jan 15 |
Angiogenesis and Microvascular Remodeling: Capillary
Sprouting Dynamics |
Price |
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Jan
20
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Angiogenesis
and Microvascular Remodeling: Microvessel Maturation |
Peirce-Cottler |
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Jan22 |
Vascular Smooth
DIFFERENTIATION |
Owens |
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Jan 27 |
Tumor Angiogenesis |
Tucker |
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Jan 29 |
Controversy in vascular biology |
Students |
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BIOLOGY OF VASCULAR CELLS |
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Feb 3 |
Endothelial
cell biology IIII – Paracrine Signaling |
Isakson |
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Feb 5 |
Endothelial Cell
Biology II - Cytoskeleton |
Helmke |
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Feb 10 |
Endothelal Cell Biology
I - Matrix |
Schwartz |
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Feb 12 |
Vascular Smooth
Muscle Cell Biology I– the contractile process |
Somlyo,
Wamhoff |
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Feb 17 |
Vascular Smooth
Muscle Cell Biology II – intracellular signaling cascades |
Somlyo,
Wamhoff |
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Feb. 19 |
Platelet Biology |
Gear |
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Feb 24 |
Leukocyte biology |
Ley |
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Feb 26 |
LEUKOCYTES IN
INFLAMMATION |
Ley |
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Mar 3 |
Spring Recess |
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Mar 5 |
Spring Recess |
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Mar 10 |
Controversy in
vascular biology |
Students |
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Principles of
Vascular Function |
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Mar 12 |
CAPILLARY EXCHANGE AND ENDOTHELIAL CELL
PERMEABILITY |
Duling
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Mar 17 |
VASCULAR CELL-CELL COMMUNICATION |
Isakson |
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Mar 19 |
INTRINSIC VASCULAR CONTROL PROCESSES |
Duling |
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Mar 24 |
Controversy in vascular biology |
Students |
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Mar 26 |
Hemodynamics and Vascular
Cell Responses |
Blackman |
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Mar 31 |
NEURAL VASCULAR CONTROL PROCESSES |
Guyenet |
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Apr 2 |
Controversy in
vascular biology |
Students |
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Vascular Pathophysiology |
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April
7
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VASCULAR INFLAMMATION |
Linden |
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April 9 |
HEMOSTASIS/THROMBOSIS |
Gear |
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April 14 |
Controversy in vascular biology |
Students |
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April 16 |
HYPERTENSION |
Carey |
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April 21 |
Experimental Biology Meetings |
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April 23 |
ATHEROSCLEROSIS |
McNamara |
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April 28 |
DIABETES |
Hedrick |
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May 2 |
Reading day |
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May 5
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Final Exam |
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May 16 |
Vascular Biology Luncheon - The Lawn Garden Pavillion 8 - 12pm
to 2pm |
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EXAMPLES OF STUDENT
TOPICS
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Athrosclerosis Vulnerable Plaque Smooth muscle growth
triggers The role of the
adventitia in regulating neointimal growth A
role for B Lymphocytes? Are
foam cells within atherosclerotic lesions derived exclusively from
macrophages? |
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ENDOTHELIUM Circulating stem
cells can give rise to either endothelial cells, or SMC within the peripheral
vasculature |
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ATHEROSCLEROSIS Atero is the result
of altered bulk phase pinocytosis not unregulated uptake of oxid LDL by the
scavenger LDL receptor. |
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ANGIOGENESIS Matrix in angiogenesis Mesenchymal origin of vessel wall cells Stimuli to angiogenesis Capillary adaptation to use Stem cells and angiogenesis |
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Bone
marrow-derived SMCs and vascular disease Do bone marrow-derived stem
cells give rise to SMCs in neointimal hyperplasia. |
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neural
vascular control Receptor heterogeneity Synthetic processes NO as a transmitter Co-transmitter release Role of ATP Presynaptic regulation |
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CLOTTING AND THROMBOLYSIS Endothelium and
hemostasis Thrombin in
hemostasis and cellular growth |
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NEUTROPHIL-ENDOTHELIAL CELL
INTERACTIONS The oxidative burst Adhesion moleculespx White cell viscosity and resistance Addressins and the high endothelium |
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VASCULAR INFLAMMATION Cytokines and inflammation Autoimmunity |
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SMOOTH
MUSCLE-ENDOTHELIAL CELL COMMUNICATION Gap junctions? |
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SMOOTH MUSCLE
CONTRACTION Regulation of myosin light
chain phosphatase Calcium independent
contractions Intracellular Ca++ stores in smooth muscle and
endothelium |
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ENDOTHELIAL CELL SIGNALING NO and wall shear stress Endothelin and sepsis Endothelin and hypertension NO – cGMP inhibitory pathway |
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